R. Edwards

Publications252
h-index50
Citations7,856
Highly Influential Citations349
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S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.
Checkpoints that respond to DNA structure changes were originally defined by the inability of yeast mutants to prevent mitosis following DNA damage or S-phase arrest. Genetic analysis has… Expand
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Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells
1. Cultured hepatic cells have reduced cytochrome P450 (CYP) activities in comparison with human liver, but the mechanism(s) that underlies this circumstance is not clear. We investigated the causes… Expand
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Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism.
To study mechanisms behind the interindividual variability in CYP3A expression and the relative contribution of the different CYP3A enzymes to the overall CYP3A activity, we have analyzed CYP3A4,… Expand
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Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes.
Lethal necrotizing fasciitis caused by Streptococcus pyogenes is characterized by a paucity of neutrophils at the site of infection. Interleukin (IL)-8, which is important for neutrophil… Expand
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A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking.
1. In previous studies (Boobis et al., 1985b) it was shown that a monoclonal antibody (MAb 3/4/2), raised against rat cytochrome P450 form c, reacts with an isoenzyme(s) of cytochrome P450 in human… Expand
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Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.
The expression of individual xenobiotic-metabolizing cytochrome P450 (CYP) genes in human placenta was studied at the mRNA level by reverse transcriptase-polymerase chain reaction (RT-PCR). mRNAs of… Expand
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Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans.
Mono-specific antibodies against the human cytochrome P450 (P450) enzymes CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP3A4, CYP3A5 and CYP4A11 and an antibody that binds to CYP2C8,… Expand
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Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices.
The maintenance of the major hepatic cytochrome P450 (CYP) enzymes has been studied in precision-cut human liver slices cultured for up to 72 h in supplemented RPMI 1640 medium. The relative… Expand
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Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 Å resolution
Cryo-EM of relaxed myosin filament reveals unique molecular motor conformation and unprecedented details of the filament backbone. We describe a cryo–electron microscopy three-dimensional image… Expand
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Kidney dysfunction and hypertension: role for cadmium, p450 and heme oxygenases?
Cadmium (Cd) is a metal toxin of continuing worldwide concern. Daily intake of Cd, albeit in small quantities, is associated with a number of adverse health effects which are attributable to distinct… Expand
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