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Cystamine

Known as: Cystamine [Chemical/Ingredient], 2,2'-Dithiobis(ethylamine), Decarboxycystine 
A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage.
National Institutes of Health

Related topics

Related topics

23 relations
Cystamine DihydrochlorideIn Bloodagonistsaminothiol
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Narrower (10)

Cystamine HydrochlorideCystamine SulfateDNCON,N'-bis(glycyl)cystamine
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Broader (4)

Enzyme InhibitorsRadiation-Protective AgentsSulfhydryl ReagentsSulfides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways of patients with cystic fibrosis (CF), a… Expand
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Highly Cited
2008
Highly Cited
2008
The influence of RGD addition on the gene transfer characteristics of disulfide-containing polyethyleneimine/DNA complexes.
Arginine-glycine-aspartic acid (RGD) ligand is often chemically attached to polycation vector to improve the transfection… Expand
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Highly Cited
2006
Highly Cited
2006
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the… Expand
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Highly Cited
2004
Highly Cited
2004
Long-range electrical contacting of redox enzymes by SWCNT connectors.
The combination of biological molecules and novel nanomaterial components is of great importance in the process of developing new… Expand
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Highly Cited
2003
Highly Cited
2003
Cystamine Inhibits Caspase Activity
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormally expended polyglutamine… Expand
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Highly Cited
2003
Highly Cited
2003
Probing photoelectrochemical processes in Au-CdS nanoparticle arrays by surface plasmon resonance: application for the detection of acetylcholine esterase inhibitors.
The photoelectrochemical charging of Au-nanoparticles (NP) in a Au-nanoparticle/CdS-nanoparticle array assembled on a Au-coated… Expand
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Highly Cited
2002
Highly Cited
2002
Therapeutic Effects of Cystamine in a Murine Model of Huntington's Disease
The precise cause of neuronal death in Huntington's disease (HD) is unknown. Proteolytic products of the huntingtin protein can… Expand
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Highly Cited
2002
Highly Cited
2002
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
An expanded polyglutamine domain in huntingtin underlies the pathogenic events in Huntington disease (HD), characterized by… Expand
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Highly Cited
2002
Highly Cited
2002
Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4′-dithiodipyridine
Since its introduction in 1959, Ellman's reagent (5,5′-dithio-bis(2-nitrobenzoic acid)) has been the favorite reagent for… Expand
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Highly Cited
1998
Highly Cited
1998
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch
To elucidate the molecular mechanisms whereby expanded polyglutamine stretches elicit a gain of toxic function, we expressed full… Expand
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