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Cyclin A

Known as: Adenovirus E1A Associated Protein p60, Type A Cyclin, Type A Cyclins 
A cyclin subtype that has specificity for CDC2 PROTEIN KINASE and CYCLIN-DEPENDENT KINASE 2. It plays a role in progression of the CELL CYCLE through… 
National Institutes of Health

Related topics

Related topics

11 relations
CCNA2 geneIn BloodProcess of secretionagonists

Broader (1)

Proliferating Cell Nuclear Antigen

Narrower (1)

cyclin A2

Papers overview

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Highly Cited
2006
Highly Cited
2006
Cyclin A Immunocytology as a Risk Stratification Tool for Barrett's Esophagus Surveillance
Purpose: Endoscopic surveillance of Barrett's esophagus (BE) by histopathologic biopsy assessment is suboptimal. A proliferation… 
Highly Cited
2004
Highly Cited
2004
Proteasome-Mediated Destruction of the Cyclin A/Cyclin-Dependent Kinase 2 Complex Suppresses Tumor Cell Growth in Vitro and in Vivo
Cyclin-dependent kinases (cdks) represent potentially promising molecular targets for cancer therapeutic strategies. To evaluate… 
Highly Cited
1999
Highly Cited
1999
Cyclin A Is a Functional Target of Retinoblastoma Tumor Suppressor Protein-mediated Cell Cycle Arrest*
Although RB inhibits the G1-S transition, the mechanism through which RB prevents cell cycle advancement remains unidentified. To… 
Highly Cited
1999
Highly Cited
1999
c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression.
Cyclin A1 differs from other cyclins in its highly restricted expression pattern. Besides its expression during spermatogenesis… 
Highly Cited
1998
Highly Cited
1998
The cell-cycle regulated transcription factor B-Myb is phosphorylated by Cyclin A/Cdk2 at sites that enhance its transactivation properties
Expression of the B-Myb transcription factor is upregulated during late G1 phase of the cell cycle by an E2F-dependent… 
Highly Cited
1997
Highly Cited
1997
p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression
Cyclin E is necessary and rate limiting for the passage of mammalian cells through the G1 phase of the cell cycle. Control of… 
Highly Cited
1997
Highly Cited
1997
TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins.
A specific mutation in TAFII250, the largest subunit of the transcription factor TFIID, disrupts cell growth control in the… 
Highly Cited
1996
Highly Cited
1996
Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts.
Extracts of activated Xenopus eggs in which protein synthesis has been inhibited support a single round of chromosomal DNA… 
Highly Cited
1994
Highly Cited
1994
Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase.
The human single-stranded-DNA-binding protein (HSSB, also called RP-A) is a trimeric complex (p70, p34, and p14) required for… 
Highly Cited
1993
Highly Cited
1993
Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase
Cyclins are pivotal in the coordinate regulation of the cell cycle. By physical association, they are able to activate at least… 
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