Crypt

A pitlike depression or tubular recess.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The rapid turnover of the mammalian intestinal epithelium is supported by stem cells located around the base of the crypt. In… (More)
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Highly Cited
2012
Highly Cited
2012
Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and progenitor cells; however… (More)
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Review
2008
Review
2008
An appreciation of colonic crypt organization has become essential to any understanding of tumorigenesis in the colon. Intestinal… (More)
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Highly Cited
2008
Highly Cited
2008
The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were… (More)
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Highly Cited
2007
Highly Cited
2007
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently believed that four to six… (More)
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Highly Cited
2006
Highly Cited
2006
The understanding of the fixation of mutations within human tissues and their subsequent clonal expansion is a considerable… (More)
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Highly Cited
2005
Highly Cited
2005
Wnt signalling, which is transduced through β-catenin/TCF4, maintains the undifferentiated state of intestinal crypt progenitor… (More)
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Highly Cited
2004
Highly Cited
2004
Little is known about the signaling mechanisms that determine the highly regular patterning of the intestinal epithelium into… (More)
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Highly Cited
2002
Highly Cited
2002
Villin, an actin bundling protein found in the apical brush border of absorptive tissues, is one of the first structural genes to… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Aberrant crypt foci of the colon are possible precursors of adenoma and cancer, but these lesions have been studied… (More)
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