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A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
Data provide evidence that SPGP is the human bile salt export pump (BSEP), and the product of the orthologous rat gene has been shown to be an effective bile acid transporter in vitro.
The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood.
At least one third of the patients with a progressive familial intrahepatic cholestasis type 3 phenotype have a proven defect of the multidrug resistance 3 gene (MDR3), which should also be considered in adult liver diseases.
Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells.
It is concluded that UCMSCs, with a newly demonstrated endodermic differentiation potential, might be an alternative source for liver-directed cell therapies.
Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.
With this study, >100 ABCB11 mutations are now identified and close surveillance of BSEP-deficient patients retaining their native liver, particularly those carrying 2 null mutations, is essential.
A role for autophagy during hepatic stellate cell activation.
Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis.
Recombinant gp350 vaccine for infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus…
- E. Sokal, K. Hoppenbrouwers, M. Denis
- Medicine, BiologyJournal of Infectious Diseases
- 15 December 2007
These data support the clinical feasibility of using an EBV vaccine to prevent infectious mononucleosis and there were no concerns regarding the safety or reactogenicity of the gp350/AS04 vaccine.
Immunogenicity and tolerability of recombinant serogroup B meningococcal vaccine administered with or without routine infant vaccinations according to different immunization schedules: a randomized…
A 4CMenB vaccine is immunogenic against reference strains when administered with routine vaccines at 2, 4, and 6 years of age, producing minimal interference with the response to routine infant vaccinations.
Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of Pediatric Gastroenterology, Hepatology and…
Human skin fibroblasts: From mesodermal to hepatocyte‐like differentiation
This work demonstrates that human skin fibroblasts are able to display mesodermal and endodermal differentiation capacities and provides arguments that these cells share MSCs features both on the phenotypic and functional levels.