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Cotinine

Known as: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone, Cotinine [Chemical/Ingredient], S-(-)-Cotinine 
The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Abstract Context: Electronic cigarettes (e-cigarettes) are becoming increasingly popular yet their effects on health remain… Expand
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Review
2004
Review
2004
Children's exposure to tobacco constituents during fetal development and via environmental tobacco smoke (ETS) exposure is… Expand
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Highly Cited
2002
Highly Cited
2002
Cigarette smoking is the foremost modifiable risk factor for adverse pregnancy outcomes. Nicotine is a suspected fetal… Expand
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Review
1996
Review
1996
  • N. Benowitz
  • Epidemiologic reviews
  • 1996
  • Corpus ID: 37127616
A biomarker is desirable in quantitating systemic exposure both in smokers and nonsmokers to constituents of tobacco smoke. Self… Expand
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Highly Cited
1996
Highly Cited
1996
Nicotine is primarily metabolized to cotinine, and cotinine is further metabolized to trans-3'-hydroxycotinine in human liver… Expand
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Highly Cited
1994
Highly Cited
1994
OBJECTIVES (1) To determine the disposition kinetics of nicotine and cotinine, including the fractional conversion of nicotine to… Expand
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Highly Cited
1992
Highly Cited
1992
BACKGROUND Although widely used in epidemiological studies, self-report has been shown to underestimate the prevalence of… Expand
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Highly Cited
1989
Highly Cited
1989
Two simple self-report measures have been used to assess the heaviness of smoking, 'number of cigarettes per day' (CPD) and 'time… Expand
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Highly Cited
1988
Highly Cited
1988
Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two… Expand
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Highly Cited
1985
Highly Cited
1985
Nicotine and cotinine concentrations were measured in placental tissue during the first trimester, in amniotic fluid during the… Expand
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