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hydroxycotinine

Known as: 1-methyl-3-hydroxy-5-(3-pyridyl)-2-pyrrolidinone, 3'-Hydroxycotinine, 3-Hydroxycotinine 
A metabolite of nicotine that is detectable in the urine of smokers.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Substantial variability exists in therapeutic response and adverse effects with pharmacotherapies for tobacco… Expand
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2015
2015
Background: The highly genetically variable enzyme CYP2A6 metabolizes nicotine to cotinine (COT) and COT to trans-3… Expand
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Highly Cited
2011
Highly Cited
2011
Background: Variability in smoking behavior is partly attributable to heritable individual differences in nicotine clearance… Expand
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Highly Cited
2009
Highly Cited
2009
Transdermal nicotine is widely used for smoking cessation, but only approximately 20% of smokers quit successfully with this… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Nicotine is metabolized to cotinine, and cotinine is metabolized to 3'-hydroxycotinine (3-HC) by the liver enzyme… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVE The liver enzyme cytochrome P450 (CYP) 2A6 is primarily responsible for the metabolism of nicotine… Expand
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Highly Cited
1999
Highly Cited
1999
We previously reported that the metabolism of cotinine, the proximate metabolite of nicotine, is significantly slower in black… Expand
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Highly Cited
1997
Highly Cited
1997
AIMS Nicotine nasal spray and transdermal nicotine are effective aids to smoking cessation, and are being evaluated for treatment… Expand
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Highly Cited
1994
Highly Cited
1994
The objectives of this study were to 1) quantitatively assess human exposure to various metabolites of nicotine, 2) examine the… Expand
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1988
1988
The trans-isomer of 3'-hydroxycotinine has recently been identified as a major metabolite of nicotine in urine of cigarette… Expand
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