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hydroxycotinine

Known as: 1-methyl-3-hydroxy-5-(3-pyridyl)-2-pyrrolidinone, 3'-Hydroxycotinine, 3-Hydroxycotinine 
A metabolite of nicotine that is detectable in the urine of smokers.
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Cotinine
analogs & derivatives

Narrower (1)

trans-3'-hydroxycotinine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers
Background: Tobacco exposure is often quantified by serum or saliva concentrations of the primary nicotine metabolite, cotinine… 
2015
2015
POLYMORPHISM OF CYTOCHROME P 450 2 A 6 ( CYP 2 A 6 * 1 AND CYP 2 A 6 * 4 ) AMONG JAVANESE INDONESIAN SMOKER AND NON SMOKER
1.Postgraduate Programe Pharmaceutical Science, University of Gadjah Mada, 55281. Yogyakarta, Indonesia 2Faculty of Pharmacy… 
2013
2013
High dose transdermal nicotine for fast metabolizers of nicotine: a proof of concept placebo-controlled trial.
INTRODUCTION Smokers with a faster rate of nicotine metabolism, estimated using the ratio of 3'-hydroxycotinine (3-HC) to… 
Highly Cited
2011
Highly Cited
2011
Nicotine Metabolite Ratio Predicts Smoking Topography and Carcinogen Biomarker Level
Background: Variability in smoking behavior is partly attributable to heritable individual differences in nicotine clearance… 
2011
2011
Validation of a liquid chromatography-tandem mass spectrometry method for the detection of nicotine biomarkers in hair and an evaluation of wash procedures for removal of environmental nicotine.
The aim of this exploratory study was to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS-MS) method… 
2007
2007
Prediction Methods for Nicotine Clearance Using Cotinine and 3-Hydroxy-Cotinine Spot Saliva Samples II. Model Application
To develop and compare methods that predict individual nicotine (NIC) clearance, which reflects CYP2A6 activity, using random… 
2002
2002
Genotyping human CYP2A6 variants.
1992
1992
Transdermal Nicotine
SynopsisTransdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the… 
1990
1990
Synthesis of (3'R,5'S)-trans-3'-hydroxycotinine, a major metabolite of nicotine. Metabolic formation of 3'-hydroxycotinine in humans is highly stereoselective.
A method for the synthesis of (3'R,5'S-trans-3'-hydroxycotinine, a major metabolite of nicotine in humans, is described. The… 
Highly Cited
1972
Highly Cited
1972
Structure of hydroxycotinine, a nicotine metabolite.
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