hydroxycotinine

Known as: 1-methyl-3-hydroxy-5-(3-pyridyl)-2-pyrrolidinone, 3-Hydroxycotinine, 3'-hydroxycotinine 
A metabolite of nicotine that is detectable in the urine of smokers.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
024619722017

Papers overview

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2009
2009
Transdermal nicotine is widely used for smoking cessation, but only approximately 20% of smokers quit successfully with this… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Nicotine is metabolized to cotinine, and cotinine is metabolized to 3'-hydroxycotinine (3-HC) by the liver enzyme… (More)
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2005
2005
Nicotine is rapidly and extensively metabolized in humans and negatively impacts the developing fetus. The concentrations of… (More)
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2005
2005
Nicotine is rapidly and extensively metabolized in humans. We present an analytical method to simultaneously quantify nicotine… (More)
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2003
2003
The rate of nicotine metabolism is hypothesized to be a determinant of how much a person smokes. That is, rapid metabolizers… (More)
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2000
2000
OBJECTIVE To characterize the presence of and elimination kinetics of nicotine and its metabolites in newborns. METHODS Blood… (More)
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Highly Cited
1999
Highly Cited
1999
We previously reported that the metabolism of cotinine, the proximate metabolite of nicotine, is significantly slower in black… (More)
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1997
1997
AIMS Nicotine nasal spray and transdermal nicotine are effective aids to smoking cessation, and are being evaluated for treatment… (More)
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Highly Cited
1994
Highly Cited
1994
The objectives of this study were to 1) quantitatively assess human exposure to various metabolites of nicotine, 2) examine the… (More)
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1988
1988
The trans-isomer of 3'-hydroxycotinine has recently been identified as a major metabolite of nicotine in urine of cigarette… (More)
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