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Conotoxin

Known as: Conotoxins, Conotoxins [Chemical/Ingredient] 
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly… Expand
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (38)

AnIA protein, Conus anemoneLo959 protein, Conus loroisiialpha-Conotoxinsalpha-conotoxin BuIA, Conus bullatus
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Calcium Channel BlockersConus genusIn BloodProcess of secretion
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Broader (1)

Marine Toxins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
The engineering of an orally active conotoxin for the treatment of neuropathic pain.
From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain… Expand
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Highly Cited
2005
Highly Cited
2005
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant
Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and… Expand
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Highly Cited
1998
Highly Cited
1998
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants.
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic… Expand
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Highly Cited
1997
Highly Cited
1997
Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices.
In the present study we investigated electrophysiologically the nicotinic responses of pyramidal neurons and interneurons… Expand
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Highly Cited
1996
Highly Cited
1996
A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors.
We have isolated a 16-amino acid peptide from the venom of the marine snail Conus magus which potently blocks nicotinic… Expand
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Highly Cited
1993
Highly Cited
1993
Nifedipine- and omega-conotoxin-sensitive Ca2+ conductances in guinea-pig substantia nigra pars compacta neurones.
1. The membrane properties of substantia nigra pars compacta (SNc) neurones were recorded in guinea-pig in vitro brain slices. 2… Expand
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Highly Cited
1992
Highly Cited
1992
Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.
N-type calcium channels are omega-conotoxin (omega-CgTx)-sensitive, voltage-dependent ion channels involved in the control of… Expand
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Highly Cited
1992
Highly Cited
1992
Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.
  • K. Mackie, B. Hille
  • Proceedings of the National Academy of Sciences…
  • 1992
    • Corpus ID: 25518023
The psychoactive properties of Cannabis sativa and its major biologically active constituent, delta 9-tetrahydrocannabinol, have… Expand
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Highly Cited
1987
Highly Cited
1987
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle.
Blockade of Ca2+ channels by omega-conotoxin GVIA, a 27 amino acid peptide from the venom of the marine snail Conus geographus… Expand
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Highly Cited
1987
Highly Cited
1987
Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.
The omega-conotoxins from the venom of fish-hunting cone snails are probably the most useful of presently available ligands for… Expand
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