Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
- D. Games, David John Adams, Jun Zhao
- Biology, ChemistryNature
- 9 February 1995
Transgenic mice that express high levels of human mutant APP support a primary role for APP/Aβ in the genesis of AD and could provide a preclinical model for testing therapeutic drugs.
The permeability of the endplate channel to organic cations in frog muscle
- T. Dwyer, David John Adams, B. Hille
- BiologyThe Journal of General Physiology
- 1 May 1980
The relative permeability of endplate channels to many organic cations was determined by reversal-potential criteria and specific chemical factors seem to be less important than access or friction in determining the ionic selectivity of the endplate channel.
Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*
- R. Lewis, K. Nielsen, P. Alewood
- BiologyJournal of Biological Chemistry
- 10 November 2000
In electrophysiological studies, ω-conotoxins CVID and MVIIA had similar potencies to inhibit current through central and peripheral splice variants of the rat N-type calcium channels when coexpressed with rat β3 in Xenopus oocytes, but the potency of CVID increased when α1B-d and α1b-b were expressed in the absence of ratβ3.
The permeability of endplate channels to monovalent and divalent metal cations
- David John Adams, T. Dwyer, B. Hille
- BiologyThe Journal of General Physiology
- 1 May 1980
Permeability ratios for divalent ions decreased as the concentration of divalent ion was increased in a manner consistent with the negative surface potential theory of Lewis (1979 J. Physiol.
Ion channels and regulation of intracellular calcium in vascular endothelial cells
- David John Adams, J. Barakeh, R. Laskey, C. van Breemen
- BiologyThe FASEB Journal
- 1 October 1989
Oscillations in [Ca2+]i, which may involve both Ca2+ entry and release, have been observed in isolated and confluent endothelial cell monolayers stimulated by histamine and bradykinin, and are consistent with a cycle that involves the plasma membrane.
μO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
- J. Ekberg, A. Jayamanne, R. Lewis
- BiologyProceedings of the National Academy of Sciences
- 7 November 2006
It is demonstrated that μO-conotoxin MrVIB from Conus marmoreus displays substantial selectivity for Nav1.8 and inhibits pain behavior in models of persistent pain and can alleviate chronic pain behavior with a greater therapeutic index than nonselective antagonists.
Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2*
- Andrew B. Fotia, J. Ekberg, David John Adams, D. Cook, P. Poronnik, Sharad Kumar
- BiologyJournal of Biological Chemistry
- 1 July 2004
It is shown that the carboxyl termini fusion proteins of one central nervous system and one peripheral nervous system-derived Na+ channel are readily ubiquitinated by Nedd4-2, and these channels have conserved WW domain binding specificity.
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
- K. Mann, J. Ward, N. Copeland
- Biology, MedicineProceedings of the National Academy of Sciences
- 15 March 2012
Sleeping Beauty mutagenesis provides a rich resource of mutations in potential cancer drivers for cross-comparative analyses with ongoing sequencing efforts in human pancreatic adenocarcinoma.
Voltage‐dependent sodium and calcium currents in cultured parasympathetic neurones from rat intracardiac ganglia.
- Z. J. Xu, David John Adams
- BiologyJournal of Physiology
- 1 October 1992
The kinetics of activation and inactivation of the Ca2+ current were voltage dependent and the time course of inactivation was fitted by the sum of two exponentials, which increased at depolarized membrane potentials.
The Doublecortin-Expressing Population in the Developing and Adult Brain Contains Multipotential Precursors in Addition to Neuronal-Lineage Cells
- T. Walker, T. Yasuda, David John Adams, P. Bartlett
- BiologyJournal of Neuroscience
- 4 April 2007
Results indicate that DCXhigh cells, regardless of location, are restricted to the neuronal lineage or are bone fide neurons, whereas some DCXlow cells retain their multipotentiality.
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