Illawarra Health & Medical Research Institute (IHMRI), University of Wollongong
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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Transgenic mice that express high levels of human mutant APP support a primary role for APP/Aβ in the genesis of AD and could provide a preclinical model for testing therapeutic drugs.
The permeability of the endplate channel to organic cations in frog muscle
The relative permeability of endplate channels to many organic cations was determined by reversal-potential criteria and specific chemical factors seem to be less important than access or friction in determining the ionic selectivity of the endplate channel.
Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*
- R. Lewis, K. Nielsen, +12 authors P. Alewood
- Biology, MedicineThe Journal of Biological Chemistry
- 10 November 2000
In electrophysiological studies, ω-conotoxins CVID and MVIIA had similar potencies to inhibit current through central and peripheral splice variants of the rat N-type calcium channels when coexpressed with rat β3 in Xenopus oocytes, but the potency of CVID increased when α1B-d and α1b-b were expressed in the absence of ratβ3.
The permeability of endplate channels to monovalent and divalent metal cations
Permeability ratios for divalent ions decreased as the concentration of divalent ion was increased in a manner consistent with the negative surface potential theory of Lewis (1979 J. Physiol.
μO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
- J. Ekberg, A. Jayamanne, +10 authors R. Lewis
- Chemistry, MedicineProceedings of the National Academy of Sciences
- 7 November 2006
It is demonstrated that μO-conotoxin MrVIB from Conus marmoreus displays substantial selectivity for Nav1.8 and inhibits pain behavior in models of persistent pain and can alleviate chronic pain behavior with a greater therapeutic index than nonselective antagonists.
Voltage‐dependent sodium and calcium currents in cultured parasympathetic neurones from rat intracardiac ganglia.
The kinetics of activation and inactivation of the Ca2+ current were voltage dependent and the time course of inactivation was fitted by the sum of two exponentials, which increased at depolarized membrane potentials.
The Doublecortin-Expressing Population in the Developing and Adult Brain Contains Multipotential Precursors in Addition to Neuronal-Lineage Cells
- T. Walker, T. Yasuda, David John Adams, P. Bartlett
- Biology, MedicineThe Journal of Neuroscience
- 4 April 2007
Results indicate that DCXhigh cells, regardless of location, are restricted to the neuronal lineage or are bone fide neurons, whereas some DCXlow cells retain their multipotentiality.
Analgesic α-Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation
- B. Callaghan, A. Haythornthwaite, G. Berecki, R. Clark, D. Craik, David John Adams
- Chemistry, MedicineThe Journal of Neuroscience
- 22 October 2008
A novel mechanism by which α-conotoxins Vc1.1 and Rg1A modulate native N-type (CaV2.2) Ca2+ channel currents, namely acting as agonists via G-protein-coupled GABAB receptors is proposed, potentially mediating their analgesic actions.
ω-Conotoxin CVID Inhibits a Pharmacologically Distinct Voltage-sensitive Calcium Channel Associated with Transmitter Release from Preganglionic Nerve Terminals*
- David John Adams, Amanda Smith, C. Schroeder, T. Yasuda, R. Lewis
- Chemistry, MedicineThe Journal of Biological Chemistry
- 7 February 2003
The results indicate that ω-conotoxin CVID from Conus catus inhibits a pharmacologically distinct voltage-sensitive calcium channel involved in neurotransmitter release, whereas ω -conotoxins MVIIA had no effect.
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
- K. Mann, J. Ward, +15 authors N. Copeland
- Biology, MedicineProceedings of the National Academy of Sciences
- 15 March 2012
Sleeping Beauty mutagenesis provides a rich resource of mutations in potential cancer drivers for cross-comparative analyses with ongoing sequencing efforts in human pancreatic adenocarcinoma.