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Complement component C5

Known as: C5, Complement, Complement, C5, Complement C5 
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT… 
National Institutes of Health

Related topics

Related topics

24 relations
C5 geneChemotaxisComplement ActivationComplement C5:MCnc:Pt:Ser/Plas:Qn

Narrower (3)

C5-peptideComplement component 5 deficiencycomplement C5b-7 complex

Broader (2)

Complement C5, PrecursorImmunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A case of relapsing and refractory catastrophic anti-phospholipid syndrome successfully managed with eculizumab, a complement 5 inhibitor.
peaks characteristic of MSU crystals in one control patient with OA who did not meet the classification criteria for gout [6] is… 
Review
2008
Review
2008
Antibodies, isotypes and complement in allograft rejection.
PURPOSE OF REVIEW Classical complement activation is a key step in the process of antibody-mediated rejection. Emphasizing novel… 
2003
2003
C5 is required for CD49d expression on neutrophils and VCAM expression on vascular endothelial cells following mesenteric ischemia/reperfusion.
Highly Cited
2000
Highly Cited
2000
Functional Role of the Noncatalytic Subunit of Complement C5 Convertase1
The C5 convertase is a serine protease that consists of two subunits: a catalytic subunit which is bound in a Mg2+-dependent… 
Highly Cited
1996
Highly Cited
1996
Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5
Since severe periodontitis is characterized by an acute inflammatory response with cellular infiltration and microbial overgrowth… 
1991
1991
Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family.
1991
1991
T-cell receptor V beta haplotype and complement component C5 play no significant role for the resistance to collagen-induced arthritis in the SWR mouse.
The importance of T-cell receptor (TcR) V beta gene haplotype and complement component C5 deficiency for the resistance to… 
Highly Cited
1988
Highly Cited
1988
Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9.
A human C5 clone (pC5HG2) was isolated from a cDNA library constructed from Hep G2 mRNA. The DNA sequence showed that the pC5HG2… 
1981
1981
The conversion of human complement component C5 into fragment C5b by the alternative-pathway C5 convertase.
The cleavage of human complement component C5 to fragment C5b by the alternative pathway C5 convertase was studied. The… 
Highly Cited
1977
Highly Cited
1977
Relationships between complement activation, complement binding, and EBV absorption by human hematopoietic cell lines.
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