Complement C3 Nephritic Factor
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BACKGROUND AND OBJECTIVES
The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the… Expand Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is… Expand We describe the clinical features of 28 patients with juvenile dermatomyositis (JDM) and 1 patient with adult-onset… Expand Introduction: Abnormal control of the complement alternative pathway (CAP) (factor H, factor I and membrane cofactor protein (MCP… Expand Increased monocyte/macrophage (Mφ) apoptosis occurs in patients with systemic lupus erythematosus (SLE) and is mediated, at least… Expand Abstract. The association of a C3 splitting activity, known as C3 nephritic factor (C3NeF), with mesangiocapillary… Expand The IgG fraction of serum from patients with membranoproliferative glomerulonephritis (MPGN) types I and II or partial… Expand C3 nephritic factor is an IgG autoantibody that causes complement activation by stabilizing the alternative pathway C3 convertase… Expand Complement C3 nephritic factor (NeF) produces alternative pathway-meciated C3 cleavage by binding to and stabilizing the… Expand C3 nephritic factor (C3NeF) defined by the capacity of nephritic serum and its fractions to initiate loss of the B antigen of C3… Expand