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Complement C3 Nephritic Factor

Known as: Complement C3 Nephritic Factor [Chemical/Ingredient], C3 Nephritic Factor, C 3 Nephritic Factor 
An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding… Expand
National Institutes of Health

Related topics

Related topics

9 relations

Broader (2)

Complement Inactivating AgentsImmunologic Factors
Process of secretionagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Eculizumab for dense deposit disease and C3 glomerulonephritis.
BACKGROUND AND OBJECTIVES The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the… Expand
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Highly Cited
2010
Highly Cited
2010
Anti-factor B autoantibody in dense deposit disease.
Dense deposit disease (DDD), also known as membranoproliferative glomerulonephritis type II, is a rare kidney disorder that is… Expand
Highly Cited
2008
Highly Cited
2008
Predictors of Acquired Lipodystrophy in Juvenile-Onset Dermatomyositis and a Gradient of Severity
We describe the clinical features of 28 patients with juvenile dermatomyositis (JDM) and 1 patient with adult-onset… Expand
Highly Cited
2006
Highly Cited
2006
Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome
Introduction: Abnormal control of the complement alternative pathway (CAP) (factor H, factor I and membrane cofactor protein (MCP… Expand
Highly Cited
2006
Highly Cited
2006
Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus1
Increased monocyte/macrophage (Mφ) apoptosis occurs in patients with systemic lupus erythematosus (SLE) and is mediated, at least… Expand
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Review
1997
Review
1997
C3 nephritic factor and mesangiocapillary glomerulonephritis
Abstract. The association of a C3 splitting activity, known as C3 nephritic factor (C3NeF), with mesangiocapillary… Expand
Highly Cited
1990
Highly Cited
1990
Two types of C3 nephritic factor: properdin-dependent C3NeF and properdin-independent C3NeF.
The IgG fraction of serum from patients with membranoproliferative glomerulonephritis (MPGN) types I and II or partial… Expand
1990
1990
Familial incidence of C3 nephritic factor, partial lipodystrophy and membranoproliferative glomerulonephritis.
C3 nephritic factor is an IgG autoantibody that causes complement activation by stabilizing the alternative pathway C3 convertase… Expand
Highly Cited
1977
Highly Cited
1977
Heterogeneity of nephritic factor and its identification as an immunoglobulin.
Complement C3 nephritic factor (NeF) produces alternative pathway-meciated C3 cleavage by binding to and stabilizing the… Expand
Highly Cited
1976
Highly Cited
1976
C3 nephritic factor (C3NeF): stabilization of fluid phase and cell-bound alternative pathway convertase.
C3 nephritic factor (C3NeF) defined by the capacity of nephritic serum and its fractions to initiate loss of the B antigen of C3… Expand
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