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Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction.
- A. Mungantiwar, A. Nair, +4 authors K. Sainis
- Biology, MedicineJournal of ethnopharmacology
- 1 May 1999
The present study has shown the in vivo immunostimulatory activity of B. diffusa alkaloidal fraction without an in vitro effect.
CD4+ T cell lines with selective patterns of autoreactivity as well as CD4- CD8- T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNA autoantibodies in the NZB x SWR…
Production of nephritogenic autoantibodies with IdLNF1 markers in the SNF1 mice could result from an interaction between a select population of B cells and CD4+ Th that preferentially recognize unique F1-hybrid-MHC determinants, as well as double-negative auxiliary Th.
Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols
- R. Checker, D. Sharma, +4 authors K. Sainis
- Biology, MedicineJournal of cellular biochemistry
- 1 August 2010
The results for the first time show that antiproliferative effects of plumbagin are mediated by modulation of cellular redox and provide a rationale for application of thiol‐depleting agents as anti‐inflammatory drugs.
An immunologically active arabinogalactan from Tinospora cordifolia.
Purified polysaccharide showed polyclonal mitogenic activity against B-cells, their proliferation did not require macrophages.
Low dose radiation induced immunomodulation: Effect on macrophages and CD8+ T cells
- R. Pandey, B. Shankar, D. Sharma, K. Sainis
- Biology, MedicineInternational journal of radiation biology
- 1 January 2005
The expression of early activation antigen, CD69, was enhanced in CD8+ T lymphocytes concomitant with enhanced proliferation in response to con A, and mixed lymphocyte reaction (MLR) and CTL response were augmented and secretion of interferon gamma was suppressed following LDR exposure.
Prodigiosins as anti cancer agents: living upto their name.
Though the molecular targets of prodigiosins have not been clearly defined, they have been found to target different signaling pathways possibly through induction of DNA double strand breaks and/ or neutralization of pH gradients leading to changes in cell cycle proteins and apoptosis.
TGF-β1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells.
It is found that pro-inflammatory cytokines secreted by macrophages induce TGF-β1 in tumor cells, which activate pCREB signaling, epithelial-mesenchymal-transition (EMT) responses and enhanced migration.
Purification and characterization of a lectin from wild sunflower (Helianthus tuberosus L.) tubers.
- K. Suseelan, R. Mitra, R. Pandey, K. Sainis, T. G. Krishna
- Biology, MedicineArchives of biochemistry and biophysics
- 15 November 2002
The HTTL showed characteristics different from those of the earlier reported H. tuberosus tuber lectins and hence opens up a new avenue to investigate the structure-function relationship of lectin in Helianthus species.
Immunomodulatory effect of Tylophora indica on Con A induced lymphoproliferation.
It is indicated that tylophora alkaloids have a concentration dependent biphasic effect on Con A induced mitogenesis and at lower concentrations they augment Con Ainduced lymphoproliferation by enhancing IL-2 production.
G1-4A, a Polysaccharide from Tinospora cordifolia Inhibits the Survival of Mycobacterium tuberculosis by Modulating Host Immune Responses in TLR4 Dependent Manner
It is demonstrated that modulation of host immune responses by G1-4A might improve the therapeutic efficacy of existing anti-tubercular drugs and provide an attractive strategy for the development of alternative therapies to control tuberculosis.