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Colforsin

Known as: Coleonol, N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl, Forskolin 
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive… 
National Institutes of Health

Related topics

Related topics

24 relations

Narrower (11)

1,9-dideoxyforskolin1-acetyl-7-deacetylforskolin14,15-dihydroforskolin7-bromoacetyl-7-desacetylforskolin

Broader (6)

Bronchodilator AgentsCardiotonic AgentsDiterpenesImmunologic Adjuvants
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1998
1998
Mechanism of β-Adrenergic Receptor Upregulation Induced by ACE Inhibition in Cultured Neonatal Rat Cardiac Myocytes Roles of Bradykinin and Protein Kinase C
Background—Although bradykinin is thought to contribute to the effects of ACE inhibitors on the cardiovascular system, its… 
1993
1993
Drugs of Abuse, Immunity, and AIDS
Drawn from a June 1992 international conference in Clearwater Beach, Florida, 39 papers report the latest findings and thought… 
Highly Cited
1992
Highly Cited
1992
Direct inhibitory mechanisms of halothane on canine tracheal smooth muscle contraction.
Halothane directly relaxes airway smooth muscle. To determine the direct inhibitory mechanisms of halothane on canine tracheal… 
Highly Cited
1990
Highly Cited
1990
Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells.
Two cyclic nucleotide phosphodiesterase (PDE) activities were identified in pig aortic endothelial cells, a cyclic GMP-stimulated… 
1988
1988
Formation of forskolin by suspension cultures of Coleus forskohlii.
Highly Cited
1987
Highly Cited
1987
Luteinizing hormone-induced intracellular calcium mobilization in granulosa cells: comparison with forskolin and 8-bromo-adenosine 3',5'-monophosphate.
Digitonin-permeabilized avian granulosa cells were used as a model to study the effects of LH, 8-bromo-cAMP (8-Br-cAMP), and… 
1986
1986
Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis.
The intracellular signals generated by carbachol activation of the muscarinic receptor [release of inositol phosphates as a… 
Highly Cited
1985
Highly Cited
1985
Evidence for a role for cellular alkalinization in the cyclic adenosine 3',5'-monophosphate-mediated initiation of motility in bovine caput spermatozoa.
Bicarbonate ion, the local anesthetics procaine and dibucaine, and the ionophores monensin and nigericin have been shown to… 
Highly Cited
1984
Highly Cited
1984
Forskolin-induced activation of adenylate cyclase, cyclic adenosine monophosphate production and insulin release in rat pancreatic islets.
Forskolin activated adenylate cyclase in rat islet homogenates and stimulated cAMP production in intact islets incubated in the… 
Highly Cited
1983
Highly Cited
1983
Occurrence of an inhibitory guanine nucleotide-binding regulatory component of the adenylate cyclase system in cyc- variants of S49 lymphoma cells.
In membranes of S49 lymphoma cyc− variants, which lack a functional guanine nucleotide-binding component (Ns protein) mediating… 
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