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Colforsin

Known as: Coleonol, N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl, Forskolin 
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive… Expand
National Institutes of Health

Papers overview

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Highly Cited
1998
Highly Cited
1998
Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells… Expand
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Highly Cited
1997
Highly Cited
1997
Leptin is a circulating hormone that is expressed abundantly and specifically in the adipose tissue1–5. It is involved in the… Expand
Highly Cited
1995
Highly Cited
1995
In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl). Its structure was determined… Expand
Highly Cited
1995
Highly Cited
1995
A heptadecapeptide was identified and purified from porcine brain tissue as a ligand for an orphan heterotrimeric GTP- binding… Expand
Highly Cited
1991
Highly Cited
1991
TIS10 is a primary response gene whose cDNA was cloned as a result of its rapid, superinducible expression in Swiss 3T3 cells in… Expand
Highly Cited
1990
Highly Cited
1990
A newly synthesized isoquinolinesulfonamide, H-89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline-sulfonamide), was shown to… Expand
Highly Cited
1989
Highly Cited
1989
In this paper, we demonstrate that phosphorylation of CREB at Ser-133 is induced 6-fold in vivo, following treatment of PC12… Expand
Highly Cited
1987
Highly Cited
1987
Many hormones act on neuroendocrine cells by activating second messenger pathways. Two of these, the phosphoinositol and cAMP… Expand
Highly Cited
1986
Highly Cited
1986
We have examined the regulation of somatostatin gene expression by cAMP in PC12 rat pheochromocytoma cells transfected with the… Expand
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Highly Cited
1981
Highly Cited
1981
The diterpene, forskolin [half-maximal effective concentration (EC50), 5-10 microM] activates adenylate cyclase [ATP… Expand
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