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Clevudine

Known as: 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyl-, 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)thymine, 1-(2-fluoro-5-methyl-beta,L-arabinofuranosyl)uracil 
A synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites… 
National Institutes of Health

Related topics

Related topics

4 relations
5-methyl-2'-fluoroarauracilanalogs & derivatives

Broader (2)

Antiviral AgentsArabinofuranosyluracil

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance.
Review
2008
Review
2008
Imaging of Cell Proliferation: Status and Prospects
Increased cellular proliferation is an integral part of the cancer phenotype. Several in vitro assays have been developed to… 
Review
2008
Review
2008
Advances in evaluation of primary brain tumors.
The evaluation of primary brain tumor is challenging. Neuroimaging plays a significant role. At diagnosis, imaging is needed to… 
Highly Cited
2004
Highly Cited
2004
Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer
PurposeFMAU (1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)thymine) is a thymidine analog that can be phosphorylated by thymidine… 
Highly Cited
2003
Highly Cited
2003
Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F…
Highly Cited
2003
Highly Cited
2003
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.
UNLABELLED The use of radiolabeled thymidine (TdR) and thymidine analogs as PET-based tracers of tumor growth rate is based on… 
Highly Cited
2002
Highly Cited
2002
Inhibitory activity of dioxolane purine analogs on wild‐type and lamivudine‐resistant mutants of hepadnaviruses
To design combination strategies for chronic hepatitis B therapy, we evaluated in vitro the inhibitory activity of 4 nucleoside… 
Highly Cited
1998
Highly Cited
1998
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.
We report a series of studies that assess the feasibility and sensitivity of imaging of herpes virus type one thymidine kinase… 
Highly Cited
1996
Highly Cited
1996
Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents.
Since 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU) has been shown to be a potent anti-HBV agent in vitro, it was of… 
Highly Cited
1996
Highly Cited
1996
Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications…
The capacity of recombinant human cytosolic thymidine kinase (TK1) and bovine mitochondrial thymidine kinase (TK2) to… 
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