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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.
- R. Pauwels, J. Balzarini, +5 authors E. De Clercq
- Biology, Medicine
- Journal of virological methods
- 1 August 1988
A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation of anti-HIV agents. An HTLV-I transformed T4-cell line, MT-4, which was previously shown by Koyanagi et al.… Expand
Synthetic Genetic Polymers Capable of Heredity and Evolution
Unnatural Bases The genetic basis of all life on the planet is comprised of deoxyribonucleic acid (DNA) with four nitrogenous nucleotide bases, abbreviated to A, G, C, and T. But there are variations… Expand
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties.
Human granulocyte chemotactic protein 2 (GCP-2) has originally been isolated from cytokine-stimulated osteosarcoma cells as a chemokine coproduced in minute amounts together with interleukin 8. Human… Expand
Modifications in Lignin and Accumulation of Phenolic Glucosides in Poplar Xylem upon Down-regulation of Caffeoyl-Coenzyme A O-Methyltransferase, an Enzyme Involved in Lignin Biosynthesis*
- H. Meyermans, K. Morreel, +13 authors W. Boerjan
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 24 November 2000
Caffeoyl-coenzyme AO-methyltransferase (CCoAOMT) methylates, in vitro, caffeoyl-CoA and 5-hydroxyferuloyl-CoA, two possible precursors in monolignol biosynthesis in vivo. To clarify the in vivo role… Expand
Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains
- T. Wakabayashi, K. Craessaerts, +10 authors B. Strooper
- Biology, Medicine
- Nature Cell Biology
- 1 November 2009
γ-Secretase, an aspartyl protease that belongs to the iCLiPs (intramembrane cleaving proteases) family, is a multiprotein complex that consists of presenilin (PS), nicastrin (NCT), Aph-1 and Pen-2… Expand
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.
- J. Balzarini, P. Herdewijn, E. De Clercq
- Medicine, Biology
- The Journal of biological chemistry
- 15 April 1989
3'-Azido-2',3'-dideoxythymidine (AZT) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T) are potent and selective inhibitors of human immunodeficiency virus replication in MT-4 and ATH8 cells. They are… Expand
Exploring the active site of herpes simplex virus type‐1 thymidine kinase by X‐ray crystallography of complexes with aciclovir and other ligands
Antiherpes therapies are principally targeted at viral thymidine kinases and utilize nucleoside analogs, the triphosphates of which are inhibitors of viral DNA polymerase or result in toxic effects… Expand
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.
- L. Delang, Nidya A Segura Guerrero, +13 authors P. Leyssen
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
- 1 October 2014
OBJECTIVES T-705, also known as favipiravir, is a small-molecule inhibitor that is currently in clinical development for the treatment of influenza virus infections. This molecule also inhibits the… Expand
Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids
It is argued that genetic proliferation should be rationally extended so as to enable the propagation in vivo of additional types of nucleic acids (XNA for 'xeno-nucleic acids'), whose chemical… Expand
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
In contrast to thymine and 5-fluorouracil (FUra) which were cleared from the bloodstream within 2-4 h after their i.p. administration (200 mumol/kg) to rat, (E)-5-(2-bromovinyl)uracil (BVUra)… Expand