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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
Cerebral Blood Flow Changes After Treatment of Social Phobia with the Neurokinin-1 Antagonist GR205171, Citalopram, or Placebo
In vitro and in vivo primate evaluation of carbon-11-etomidate and carbon-11-metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors.
- M. Bergström, T. Bonasera, B. Långström
- Biology, MedicineJournal of nuclear medicine : official…
- 1 June 1998
Investigations indicate that 11C-etomidate and 12C-metomidate have the potential to be useful specific agents for the visualization of the normal adrenal cortex and to provide positive identification of adrenal cortical tumors.
Correction for Scattered Radiation in a Ring Detector Positron Camera by Integral Transformation of the Projections
- M. Bergström, L. Eriksson, C. Bohm, G. Blomqvist, J. Litton
- Physics, MathematicsJournal of computer assisted tomography
- 1 February 1983
A “deconvolution” algorithm for the determination of the scatter contribution in positron emission tomography is described and the level of scattered radiation can be reduced from 25 to 1% of the total count rate in the center of the projection from a homogeneous phantom.
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant
In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography
Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel®) in patients with schizophrenia
- O. Gefvert, M. Bergström, B. Långström, T. Lundberg, L. Lindström, R. Yates
- Medicine, PsychologyPsychopharmacology
PET data shows that quetiapine has a relatively low affinity for dopamine D2 receptors, with an occupancy half-life (10 h), which was about twice as long as that for plasma, which could suggest that the combination of D2/5HT2 receptor blockade contributes to the antipsychotic effect and a low incidence of EPS seen with quetuapine in comparative phase three trials.
Changes in mACh, NMDA and GABAA receptor binding after lateral fluid‐percussion injury: in vitro autoradiography of rat brain frozen sections
- S. Sihver, N. Marklund, L. Hillered, B. Långström, Y. Watanabe, M. Bergström
- BiologyJournal of neurochemistry
- 1 August 2001
The finding of a decreased BP demonstrates the involvement of these receptor systems in the development of cellular dysfunction, which is widespread and not limited to the site of lateral FPI.
Determination of Object Contour from Projections for Attenuation Correction in Cranial Positron Emission Tomography
- M. Bergström, J. Litton, L. Eriksson, C. Bohm, G. Blomqvist
- MedicineJournal of computer assisted tomography
- 1 April 1982
In testing the influence of the skull bone on the PET values, it was found that ignoring the higher attenuation coefficient of bone in the attenuation correction caused an error in the determination of activity of 11% peripherally and 6% centrally in the object.
Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development
- M. Bergström, A. Grahnén, B. Långström
- Biology, MedicineEuropean Journal of Clinical Pharmacology
- 22 August 2003
A complete pre-clinical package including limited toxicity assessment is proposed as a base for the regulatory framework of the PET-microdosing concept, and a methodological scrutinising of the concept is presented.