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Claudin-2

Known as: Claudin 2, Claudin-2 [Chemical/Ingredient] 
A claudin subtype that is associated with the formation of cation-selective channels and increased epithelial permeability. It is localized to the… 
National Institutes of Health

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CLDN2 geneIn BloodProcess of secretionagonists

Papers overview

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Highly Cited
2015
Highly Cited
2015
EGF Regulates Claudin‐2 and ‐4 Expression Through Src and STAT3 in MDCK Cells
Epidermal Growth Factor (EGF) is a key regulator of epithelial paracellular permeability, a property that depends on tight… 
2014
2014
Safety, efficacy, and molecular mechanism of claudin-1-specific peptides to enhance blood-nerve-barrier permeability.
2013
2013
Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines.
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the… 
2012
2012
Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression
Slp2-a is required for targeting of the signaling molecule podocalyxin to the apical membrane in MDCK II cells in a Rab27A… 
2009
2009
Molecular Basis for Cation Selectivity in Claudin‐2–Based Pores
Claudins are transmembrane tight junction proteins that form paracellular pores. Claudins regulate the permeability of small… 
2009
2009
Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells
The polarization of hepatocytes involves formation of functionally distinct sinusoidal (basolateral) and bile canalicular (apical… 
Highly Cited
2008
Highly Cited
2008
Anti-invasive and Antimetastatic Activities of Ribosomal Protein S6 Kinase 4 in Breast Cancer Cells
Purpose: We have previously shown that p90 ribosomal protein S6 kinase 4 (RSK4), an X-linked gene, is highly up-regulated in… 
Highly Cited
2007
Highly Cited
2007
Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance.
Heparin-binding (HB)-EGF, a ligand for EGF receptors, is synthesized as a membrane-anchored precursor that is potentially capable… 
Highly Cited
2006
Highly Cited
2006
Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies.
Highly Cited
2005
Highly Cited
2005
Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis
BackgroundThe esophageal tight junction is responsible for the paracellular sealing of the epithelium. Alteration of the… 
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