Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells

  title={Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells},
  author={Seiichi Son and Takashi Kojima and Catherine Decaens and Hiroshi Yamaguchi and Tatsuya Ito and Masafumi Imamura and Masaki Murata and Satoshi Tanaka and Hideki Chiba and Koichi Hirata and Norimasa Sawada},
  journal={Histochemistry and Cell Biology},
The polarization of hepatocytes involves formation of functionally distinct sinusoidal (basolateral) and bile canalicular (apical) plasma membrane domains that are separated by tight junctions. Although various molecular mechanisms and signaling cascades including polarity complex proteins may contribute to bile canalicular formation in hepatocytes, the role of tight junction proteins in bile canalicular formation remains unclear. To investigate the role of the integral tight junction protein… CONTINUE READING


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