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Ciluprevir

Known as: (2R,6S,12Z,13aS,14aR,16aS)-6-(((Cyclopentyloxy)carbonyl)amino)-2-((7-methoxy-2-(2-((1-methylethyl)amino)thiazol-4-yl)quinolin-4-yl)oxy)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa(e)pyrrolo(1,2-a)(1,4)diazacyclopentadecine-14a(5H)-carboxylic acid 
An orally bioavailable, peptidomimetic, macrocyclic compound with activity against hepatitis C virus (HCV). Ciluprevir binds non-covalently to the… Expand
National Institutes of Health

Papers overview

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2016
2016
OBJECTIVE Direct-acting antivirals (DAAs) inhibit hepatitis C virus (HCV) infection by targeting viral proteins that play… Expand
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2016
2016
Hepatitis C virus (HCV) currently infects over 185 million individuals around the world. Its persistence causes infected… Expand
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2015
2015
Treatment failure associated with HCV resistance to newly developed direct-acting antiviral agents is not an uncommon occurrence… Expand
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2014
2014
To aid the design of next generation hepatitis C virus (HCV) drugs, the kinetics of the interactions between NS3 protease… Expand
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2008
2008
The first potent and specific inhibitor of the NS3/4A serine protease to be tested in a randomized, placebocontrolled pilot study… Expand
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Review
2007
Review
2007
This perspective is the fifth in a series discussing drugs dropped from development in 2005, of which 11 were being developed for… Expand
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Review
2006
Review
2006
Hepatitis C virus (HCV) NS3.4A protease inhibitors have potential for treating chronic HCV disease. Robust antiviral effects have… Expand
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Review
2005
Review
2005
Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide and afflicts > 170 million people. The… Expand
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Review
2004
Review
2004
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
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2003
2003
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
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