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Glutathione transferases--structure and catalytic activity.
The glutathione transferases are recognized as important catalysts in the biotransformation of xenobiotics, including drugs as well as environmental pollutants. Multiple forms exist, and numerous…
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4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase
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Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
TLDR
Deep insights are provided into the initiation of HCV RNA synthesis and the crystal structure of JFH1 NS5B, which displays a very closed conformation that is expected to facilitate de novo initiation.
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Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.
TLDR
The catalytic properties of four human glutathione transferases (GSTs) were examined with 14 isothiocyanate (R-NCS) substrates and the incremental transition-state stabilization attributable to an increased number of methylene groups in homologous alkyl isotho-4-(methylsulphinyl)butane is similar to that previously noted for 4-hydroxyalkenals.
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Relationships between structure and interaction kinetics for HIV-1 protease inhibitors.
TLDR
The interaction between HIV-1 protease and 58 structurally diverse transition-state analogue inhibitors has been analyzed by a surface plasmon resonance based biosensor and shows that different classes of inhibitors fall into distinct clusters in maps.
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Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor
TLDR
A recently identified chimeric receptor was used to conduct an innovative fragment-library screening in combination with X-ray crystallography to identify allosteric binding sites that can modulate receptor activation and present a structural framework for different allosterics binding sites in the α7 nAChR.
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Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor.
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Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants.
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Expression of class Pi glutathione transferase in human malignant melanoma cells.
TLDR
Its intracellular concentration was significantly higher in all the melanoma cell preparations analyzed than in the non-malignant cells, supporting the view that the class Pi glutathione transferase may contribute to the drug resistance that is characteristic of malignant melanoma.
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Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.
TLDR
Ten C2-symmetric cyclic urea and sulfamide derivatives synthesized from L-mannonic gamma-lactone and D-mannitol were selected to enable elucidation of the role of stereochemistry for binding affinity and to allow evaluation of the effects of variation in the link to the P1 and P1' phenyl groups on affinity.
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