Cilastatin

Known as: (Z)-7-((R)-2-Amino-2-carboxy-ethylsulfanyl)-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid, 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-, Cilastatinum 
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
To compare efficacy and safety of a tigecycline regimen with an imipenem/cilastatin regimen in hospital-acquired pneumonia… (More)
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2010
2010
A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Complicated intra-abdominal infections (cIAI) remain challenging to treat because of their polymicrobial etiology… (More)
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Review
2005
Review
2005
Tigecycline is the first glycylcycline to be launched and is one of the very few new antimicrobials with activity against Gram… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To determine benefits of conservative versus surgical treatment in patients with necrotizing pancreatitis. SUMMARY… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVE In a randomized, double-blind, multicenter trial, ciprofloxacin/metronidazole was compared with imipenem/cilastatin for… (More)
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Highly Cited
1994
Highly Cited
1994
In a double-blind randomized trial, imipenem/cilastatin (I/C; 500 mg every 6 hours) and ampicillin/sulbactam (A/S; 3 g every 6… (More)
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1991
1991
The safety and efficacy of imipenem/cilastatin were evaluated in 21 children, ages 3 to 48 months, with bacterial meningitis… (More)
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1990
1990
We designed a multicenter study to compare tobramycin/clindamycin to imipenem/cilastatin for intra-abdominal infections. We… (More)
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Highly Cited
1985
Highly Cited
1985
The discovery of Streptomyces cattleya and its antibiotic product, thienamycin, has ushered in a new era of beta-lactam agents… (More)
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