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Cilastatin

Known as: (Z)-7-((R)-2-Amino-2-carboxy-ethylsulfanyl)-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid, 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-, Cilastatinum 
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which… 
National Institutes of Health

Related topics

Related topics

16 relations
Bacterial InfectionsCilastatin 250 MG / Imipenem 250 MG Injection [Primaxin]Cilastatin 500 MG / Imipenem 500 MG InjectionDrug Allergy

Narrower (4)

Cilastatin / ImipenemCilastatin SodiumMK 0791Primaxin

Broader (1)

Protease Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Role of EDTA and CSE1034 in curli formation and biofilm eradication of Klebsiella pneumoniae: a comparison with other drugs
Role of EDTA and CSE1034 in curli formation and biofilm eradication of Klebsiella pneumoniae : a comparison with other drugs 
1999
1999
Levofloxacin in the empirical treatment of patients with suspected bacteraemia/sepsis: comparison with imipenem/cilastatin in an open, randomized trial.
An open, randomized, multinational, multicentre study was conducted to compare the efficacy, safety and tolerability of… 
1999
1999
Rat and human membrane dipeptidase: tissue distribution and developmental changes.
1998
1998
Meropenem in elderly and renally impaired patients.
1989
1989
Single-dose kinetics of imipenem/cilastatin during continuous arteriovenous haemofiltration in intensive care patients.
The single i.v. dose kinetics of a fixed combination of imipenem/cilastatin were investigated in ten critically ill patients… 
1988
1988
Imipenem/cilastatin, an alternative treatment of pseudomonas infection in cystic fibrosis.
Imipenem, a new N-formimidoyl thienamycin was given together with cilastatin to 20 patients with cystic fibrosis and pulmonary… 
1987
1987
Combined imipenem/cilastatin and tobramycin therapy of multiresistant Pseudomonas aeruginosa in cystic fibrosis.
Ten patients with cystic fibrosis (CF) and chronic broncho-pulmonary Pseudomonas aeruginosa infection were given imipenem… 
1987
1987
Imipenem/cilastatin therapy of infections in cancer patients
Imipenem/cilastatin was administered during 153 febrile episodes occurring in cancer patients and the response rate was 68… 
1985
1985
Imipenem/cilastatin treatment of multiresistant Pseudomonas aeruginosa lung infection in cystic fibrosis.
Ten patients with cystic fibrosis and chronic broncho-pulmonary Pseudomonas aeruginosa infection received 45 mg imipenem… 
Review
1985
Review
1985
Imipenem: first of a new class of beta-lactam antibiotics.
Imipenem, the first of a new class of carbapenem antibiotics, has potent activity against most clinically important species of… 
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