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Antibiotic treatment of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function in cystic fibrosis
TLDR
Although some of the treated patients eventually developed chronic PA infection, these patients had significantly better pulmonary function at the onset of chronicPA infection compared with control patients, and there was a trend suggesting that 3 months of high‐dose treatment with colistin inhalation and oral ciprofloxacin produced the best results in terms of postponement or prevention. Expand
Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis.
TLDR
Presence of MBL variant alleles is associated with poor prognosis and early death in patients with CF and the predicted age of survival was reduced by 8 years in variant allele carriers when compared with normal homozygotes. Expand
Pathogenesis of cystic fibrosis
European Epidemiologic Registry of Cystic Fibrosis (ERCF): Comparison of major disease manifestations between patients with different classes of mutations
Summary. By August 1997, 11,749 patients with cystic fibrosis had been enrolled in the European Epidemiologic Registry of Cystic Fibrosis (ERCF). Genotype analysis had been performed on 8,963 (76%)Expand
Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients
TLDR
It is shown that Pandoraea apista must be added to the increasing list of pathogens capable of causing chronic lung infection in cystic fibrosis patients, and was transmissible among patients with CF, leading to spread of infection from the index patient to 5 patients exposed during participation in winter camps and/or hospitalization. Expand
Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment
TLDR
Chronic colonisation with Ps aeruginosa can be prevented in cystic fibrosis by early institution of anti-pseudomonas chemotherapy. Expand
Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection.
Forty patients with cystic fibrosis and chronic broncho-pulmonary Pseudomonas aeruginosa infection entered a prospective double-blind placebo-controlled study of colistin inhalation. Active treatmentExpand
Changing Epidemiology of Pseudomonas aeruginosa Infection in Danish Cystic Fibrosis Patients (1974–1995)
TLDR
Evaluating the impact of different modes of treatment and control of CF patients introduced at the Copenhagen CF Centre over the past 20 years on the changes in the epidemiology of PA found each to be associated with improved survival. Expand
Presence of cystic fibrosis‐related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis
TLDR
A cross‐sectional analysis of 7,566 patients stratified into six age groups was used to compare lung function, body mass index (BMI), and weight for age in patients with and without cystic fibrosis‐related diabetes mellitus (CFDM). Expand
Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide
TLDR
The pathogenesis is most likely an itraconazole caused increase in systemic budesonide concentration through a reduced/inhibited metabolism leading to inhibition of adrenocorticotrophic hormone secretion along with a direct inhibition of steroidogenesis. Expand
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