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Chronic myeloproliferative disorder

Known as: Myeloproliferative Disorder, MPD, Myeloproliferative Neoplasm 
A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic… 
National Institutes of Health

Related topics

Related topics

14 relations
Bone MarrowBone marrow stem cellEPSTI1 geneEPSTI1 wt Allele

Broader (1)

Myeloproliferative disease

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Safety and Efficacy of Fedratinib in Patients With Primary or Secondary Myelofibrosis: A Randomized Clinical Trial.
IMPORTANCE Myelofibrosis (MF) is a BCR-ABL-negative myeloproliferative neoplasm characterized by anemia, splenomegaly… 
Highly Cited
2009
Highly Cited
2009
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders.
Human induced pluripotent stem (iPS) cells derived from somatic cells hold promise to develop novel patient-specific cell… 
Highly Cited
2007
Highly Cited
2007
WHO classification of tumours of haematopoietic and lymphoid tissues Chronic myeloproliferative diseases Myelodysplastic / myeloproliferative diseases Chronic myelogenous leukaemia ( CML ) Chronic…
The term chronic myeloproliferative disorders was originally used by Damashek to describe the link amongst a group of acquired… 
Highly Cited
2007
Highly Cited
2007
Familial chronic myeloproliferative disorders: clinical phenotype and evidence of disease anticipation.
PURPOSE Chronic myeloproliferative disorders (CMDs) have sporadic occurrence. However, familial clustering is reported. The… 
Highly Cited
2007
Highly Cited
2007
TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations
JAK2V617F and MPLW515L/K represent recently identified mutations in myeloproliferative disorders (MPD) that cause dysregulated… 
Highly Cited
2006
Highly Cited
2006
Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis
The diagnosis of an underlying chronic myeloproliferative disorder (CMPD) is often problematic in patients with primary… 
Highly Cited
2005
Highly Cited
2005
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
Activating mutations in tyrosine kinases have been identified in hematopoietic and nonhematopoietic malignancies. Recently, we… 
Highly Cited
2004
Highly Cited
2004
JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells
Highly Cited
1995
Highly Cited
1995
Dosimetry guidelines to minimize urethral and rectal morbidity following transperineal I-125 prostate brachytherapy.
Highly Cited
1979
Highly Cited
1979
Inferior joint space arthrography and characteristics of condylar paths in internal derangements of the TMJ.
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