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Myeloproliferative disease

Known as: DISORDER MYELOPROLIFERATIVE, Myeloproliferative Disorder, Myeloproliferative disorders (incl. CML) 
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular… Expand
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Highly Cited
2010
Highly Cited
2010
TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The… Expand
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Highly Cited
2010
Highly Cited
2010
Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here… Expand
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Highly Cited
2008
Highly Cited
2008
Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The V617F mutation, which causes the substitution of phenylalanine for valine at position 617 of the Janus kinase (JAK… Expand
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Highly Cited
2006
Highly Cited
2006
Recently, a gain-of-function MPL mutation, MPLW515L, was described in patients with JAK2V617F-negative myelofibrosis with myeloid… Expand
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Highly Cited
2006
Highly Cited
2006
Background The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Human myeloproliferative disorders form a range of clonal haematological malignant diseases, the main members of which… Expand
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