Skip to search formSkip to main contentSkip to account menu

Chromosomes, Human, Pair 21

Known as: 21 chromosome, Chromosome 21 
The designation for each member of the second smallest human autosomal chromosome pair. Chromosome 21 spans around 47 million nucleotides and… 
National Institutes of Health

Related topics

Related topics

19 relations
21qANKRD30BP1 geneChromatinChromosome 21 Short Arm

Narrower (2)

Chromosome 21, tetrasomy 21qHypotonia-Cystinuria Syndrome

Broader (2)

ChromosomesChromosomes, Human, 21-22 and Y

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Chromosome 21 and Down syndrome: from genomics to pathophysiology
The sequence of chromosome 21 was a turning point for the understanding of Down syndrome. Comparative genomics is beginning to… 
Review
2000
Review
2000
The DNA sequence of human chromosome 21
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic… 
Highly Cited
2000
Highly Cited
2000
The DNA sequence of human chromosome 21.
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic… 
Highly Cited
1994
Highly Cited
1994
Down syndrome phenotypes: the consequences of chromosomal imbalance.
Down syndrome (DS) is a major cause of mental retardation and congenital heart disease. Besides a characteristic set of facial… 
Highly Cited
1992
Highly Cited
1992
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene
Several families with an early–onset form of familial Alzheimer's disease have been found to harbour mutations at a specific… 
Highly Cited
1991
Highly Cited
1991
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
The t(8;21)(q22;q22) translocation is a non-random chromosomal abnormality frequently found in patients with acute myeloid… 
Highly Cited
1991
Highly Cited
1991
Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.
A genetic component in the etiology of Alzheimer disease (AD) has been supported by indirect evidence for several years, with… 
Highly Cited
1990
Highly Cited
1990
Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes.
Radiation hybrid (RH) mapping, a somatic cell genetic technique, was developed as a general approach for constructing long-range… 
Highly Cited
1988
Highly Cited
1988
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits… 
Highly Cited
1987
Highly Cited
1987
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.
Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several families have been described in… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)