The DNA sequence of human chromosome 21

@article{Hattori2000TheDS,
  title={The DNA sequence of human chromosome 21},
  author={Masahira Hattori and Asao Fujiyama and Todd D. Taylor and Hidemi Watanabe and Takashi Yada and H.-S. Park and Atsushi Toyoda and K. Ishii and Yasushi Totoki and Dong-Kug Choi and Ei-ichi Soeda and M. Ohki and Toshihisa Takagi and Yoshiyuki Sakaki and Stefan Taudien and Karin Blechschmidt and Andreas Polley and Uwe Menzel and Jean Maurice Delabar and Kai Kumpf and R. Lehmann and David Patterson and Kathrin Reichwald and Andreas Rump and M. Schillhabel and Andreas Schudy and Wolfgang Zimmermann and Andr{\'e} Rosenthal and Jun Kudoh and Kazunori Shibuya and Kazuhiko Kawasaki and Shuichi Asakawa and Ai Shintani and Takashi Sasaki and Kentaro Nagamine and Susumu Mitsuyama and Stylianos E. Antonarakis and Shinsei Minoshima and Nobuyoshi Shimizu and Gabriele Nordsiek and Klaus Hornischer and Petra Brandt and Maren Scharfe and O. Sch{\"o}n and A. Desario and Julia Reichelt and Gerhard Kauer and Helmut Bl{\"o}cker and Juliane Ramser and Alfred Beck and S. Klages and Steffen Hennig and L. Riesselmann and Emilie Dagand and Thomas Haaf and Silke Wehrmeyer and Katja Borzym and Katheleen J. Gardiner and Dean Ni{\vz}eti{\'c} and Fiona Francis and Hans Lehrach and Richard Reinhardt and Marie-Laure Yaspo},
  journal={Nature},
  year={2000},
  volume={405},
  pages={311-319}
}
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions for common complex disorders have also been mapped to this chromosome, and loss of heterozygosity has been observed in regions associated with solid tumours. Here we report the sequence and gene catalogue of the long arm of… Expand
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