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Clinical diagnosis of Alzheimer's disease
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available. Expand
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Article abstract-Clinical criteria for the diagnosis of Alzheimer’s disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, orExpand
Human memory and the cholinergic system. A relationship to aging?
Comparisons of the memory and cognitive deficits induced by scopolamine with the performance of aged subjects revealed a marked similarity of pattern, and the possible theoretical explanations for the behavioral similarity seen with central cholinergic blockade and normal aging are discussed. Expand
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.
The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21 and provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome. Expand
Statins and the risk of dementia
Individuals of 50 years and older who were prescribed statins had a substantially lowered risk of developing dementia, independent of the presence or absence of untreated hyperlipidaemia, or exposure to nonstatin LLAs. Expand
Novel Ubiquitin Neuropathology in Frontotemporal Dementia With Valosin-Containing Protein Gene Mutations
A novel pattern of ubiquitin pathology was identified in IBMPFD that was distinct from sporadic and familial FTLD-U without VCP gene mutations, and consistent with the hypothesis that the pathology associated with V CP gene mutations is the result of impairment of Ubiquitin-based degradation pathways. Expand
Neurological Complications of Wegener's Granulomatosis
A case is presented in which neurological involvement played a prominent part in the symptomatology and to review briefly similar experiences described in the literature. Expand
Aging of the brain, entropy, and Alzheimer disease
  • D. Drachman
  • Psychology, Medicine
  • Neurology
  • 24 October 2006
Increasing entropy, manifest through a complex network of interacting ARCs, is seen as the fundamental driving cause of neural and cognitive decline in the elderly, as well as the overriding etiologic principle in further transition to sporadic AD. Expand
Memory and the hippocampal complex. II. Is memory a multiple process
FOR at least 75 years psychologists have debated whether there is a single mechanism for human memory or two separate mechanisms of differing permanence. William James, on the basis of introspectiveExpand
Synaptic loss in Alzheimer's disease and other dementias
All AD patients showed a striking decrease in synaptic staining in the outer half of the molecular layer of the dentate gyrus compared with control brains, where the density of synaptic terminals was uniform throughout. Expand