Chromosomal Instability

Known as: Chromosomal Instability [Disease/Finding], Instability, Chromosome, Chromosomal Instabilities 
The instability of chromosomes is attributed to the continuous formation of novel chromosome mutations. These mutations form at an elevated rate in… (More)

Topic mentions per year

Topic mentions per year

1959-2018
010020019592018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Although often viewed as a single disease, colorectal cancer more accurately represents a constellation of heterogeneous subtypes… (More)
  • figure 1
  • figure 2
  • table I
  • table II
  • table III
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the presence of extra centrosomes. However, a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Autophagy is a bulk degradation process that promotes survival under metabolic stress, but it can also be a means of cell death… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
We developed a computational method to characterize aneuploidy in tumor samples based on coordinated aberrations in expression of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
To define the genetic requirements for pancreatic ductal adenocarcinoma (PDA), we have targeted concomitant endogenous expression… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Aneuploidy, an abnormal chromosome number, has been recognized as a hallmark of human cancer for nearly a century; however, the… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Earlier studies of invasive breast tumors have shown that 60-80% are aneuploid and approximately 80% exhibit amplified… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Two forms of genetic instability have been described in colorectal cancer: microsatellite instability and chromosomal instability… (More)
  • figure 1
  • table 1
  • figure 3
  • table 2
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
It has long been considered that genetic instability is an integral component of human neoplasia. In a small fraction of tumours… (More)
Is this relevant?