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Gene Expression During the Life Cycle of Drosophila melanogaster
These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes. Expand
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
Sexual orientation and courtship behavior in Drosophila are regulated by fruitless (fru), the first gene in a branch of the sex-determination hierarchy functioning specifically in the central nervousExpand
Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour
The inserted yeast GAL4 gene is inserted into the fru locus by homologous recombination and data demonstrate that FruM proteins specify the neural substrates of male courtship. Expand
Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides
Genetic and molecular data suggest that sequences including and adjacent to the female-specific splice acceptor site play an important role in the regulation of dsx expression by the transformer and transformer-2 loci. Expand
The maleless protein associates with the X chromosome to regulate dosage compensation in drosophila
The maleless (mle) gene is one of four known regulatory loci required for increased transcription (dosage compensation) of X-linked genes in D. melanogaster males and a strong candidate to be a direct regulator of dosage compensation. Expand
Genes controlling essential cell-cycle functions in Drosophila melanogaster.
The terminal phenotypes exhibited by these Drosophila mitotic mutants are remarkably similar to those observed in mammalian cell-cycle mutants, suggesting that these diverse organisms use a common genetic logic to regulate and integrate the events of the cell cycle. Expand
The evolutionary dynamics of sex determination.
Studies of the evolution of sex determination, a process that appears to have elements that undergo substantial evolutionary change and others that may be conserved, could provide substantial insights into the kinds of forces that both drive and constrain the evolutionof developmental hierarchies. Expand
Sex in flies: the splice of life
In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines sex, and thus the molecular biology of sex determination in the Fruit-fly may lead to insights into the mechanisms by which alternative splicing is regulated. Expand
The genetic control of meiosis.
This work has shown that mutants with altered meiotic exchange with defective mating-type control of sporulation have an important effect on fertility and this work aims to clarify these effects. Expand
Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster.
It is shown that the tra, tra-2 and dsx loci determine sex in a cell-autonomous manner and are major regulatory loci that control the batteries of genes necessary for the development of many, and perhaps all, secondary sexual characteristics. Expand