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Celiptium

National Institutes of Health

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elliptiniumelliptinium acetate

Papers overview

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2004
2004
Celiptium-induced nephrotoxicity and lipid peroxidation in rat renal cortex
SummaryThe antitumor drug celiptium, or N2-methyl-9-hydroxyellipticinoum (NMHE), is an ellipticine derivative used in the… 
Highly Cited
1992
Highly Cited
1992
Probing intercalation and conformational effects of the anticancer drug 2-methyl-9-hydroxyellipticinium acetate in DNA fragments with circular dichroism.
Circular dichroism was applied to the analysis of drug-DNA associations. With the octanucleotide d(TGACGTCA) (octanucleotide I… 
1988
1988
A comparative model membrane study on structural effects of membrane-active positively charged anti-tumor drugs.
1988
1988
In vitro chemical eradication of small cell lung cancer: application in autologous bone marrow transplantation.
1988
1988
Hemoglobin-catalyzed transformation of elliptinium acetate into electrophilic species. Evidences for oxidative activation of the drug in human red blood cells.
1988
1988
Structure of an antitumour drug: 9-hydroxy-2,5,11-trimethyl-6H-pyridol[4,3-b]-carbazolium acetate (9-hydroxy-2-methylellipticinium acetate; Celiptium) dihydrate.
C18H17N2O. C2H3O2. 2H3O, Mr = 336.2, monoclinic, C2/c, alpha = 21.789 (2), b = 12.853 (1), c = 14.004 (2) A, beta = 114.80 (1… 
1987
1987
Peroxidase-catalysed oxidation of N2,N6-dimethyl-9-hydroxyellipticinium acetate. Evidence for the formation of an electrophilic quinone-iminium derivative.
1987
1987
Oxidative biotransformation of the antitumour agent elliptinium acetate: Structural characterization of its human and rat urinary metabolites.
1986
1986
Covalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture.
Elliptinium acetate (9-OH-NME; Celiptium) is an antineoplastic agent currently used in the treatment of metastatic breast cancer… 
1983
1983
Human and rat urinary metabolites of the antitumor drug Celiptium (N2-methyl-9-hydroxyellipticinium acetate, NSC 264137). Identification of cysteine conjugates supporting the "biooxidative alkylation…
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