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Celiptium

National Institutes of Health

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elliptiniumelliptinium acetate

Papers overview

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2004
2004
Celiptium-induced nephrotoxicity and lipid peroxidation in rat renal cortex
SummaryThe antitumor drug celiptium, or N2-methyl-9-hydroxyellipticinoum (NMHE), is an ellipticine derivative used in the… 
1993
1993
Phase II study of elliptinium acetate salvage treatment of advanced breast cancer.
Highly Cited
1992
Highly Cited
1992
Probing intercalation and conformational effects of the anticancer drug 2-methyl-9-hydroxyellipticinium acetate in DNA fragments with circular dichroism.
Circular dichroism was applied to the analysis of drug-DNA associations. With the octanucleotide d(TGACGTCA) (octanucleotide I… 
1989
1989
Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
1988
1988
A comparative model membrane study on structural effects of membrane-active positively charged anti-tumor drugs.
1988
1988
In vitro chemical eradication of small cell lung cancer: application in autologous bone marrow transplantation.
1988
1988
Relationships between physicochemical and biological properties in a series of oxazolopyridocarbazole derivatives (OPCd); comparison with related anti-tumor agents.
Oxazolopyridocarbazole derivatives (OPCd) are intercalating polycyclic molecules related to the anti-tumor drug 9… 
1987
1987
Peroxidase-catalysed oxidation of N2,N6-dimethyl-9-hydroxyellipticinium acetate. Evidence for the formation of an electrophilic quinone-iminium derivative.
1987
1987
Oxidative biotransformation of the antitumour agent elliptinium acetate: Structural characterization of its human and rat urinary metabolites.
1986
1986
Covalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture.
Elliptinium acetate (9-OH-NME; Celiptium) is an antineoplastic agent currently used in the treatment of metastatic breast cancer… 
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