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Celiptium

National Institutes of Health

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elliptiniumelliptinium acetate

Papers overview

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2004
2004
Celiptium-induced nephrotoxicity and lipid peroxidation in rat renal cortex
SummaryThe antitumor drug celiptium, or N2-methyl-9-hydroxyellipticinoum (NMHE), is an ellipticine derivative used in the… 
1988
1988
A comparative model membrane study on structural effects of membrane-active positively charged anti-tumor drugs.
1988
1988
In vitro chemical eradication of small cell lung cancer: application in autologous bone marrow transplantation.
1988
1988
Hemoglobin-catalyzed transformation of elliptinium acetate into electrophilic species. Evidences for oxidative activation of the drug in human red blood cells.
1988
1988
Structure of an antitumour drug: 9-hydroxy-2,5,11-trimethyl-6H-pyridol[4,3-b]-carbazolium acetate (9-hydroxy-2-methylellipticinium acetate; Celiptium) dihydrate.
C18H17N2O. C2H3O2. 2H3O, Mr = 336.2, monoclinic, C2/c, alpha = 21.789 (2), b = 12.853 (1), c = 14.004 (2) A, beta = 114.80 (1… 
1987
1987
Peroxidase-catalysed oxidation of N2,N6-dimethyl-9-hydroxyellipticinium acetate. Evidence for the formation of an electrophilic quinone-iminium derivative.
1987
1987
Oxidative biotransformation of the antitumour agent elliptinium acetate: Structural characterization of its human and rat urinary metabolites.
1986
1986
Covalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture.
Elliptinium acetate (9-OH-NME; Celiptium) is an antineoplastic agent currently used in the treatment of metastatic breast cancer… 
1984
1984
Traitement des cancers primitif du foie par l'acétate d'elliptinium. 2-N-méthyl-9-hydroxy ellipticinium (NMHE), celiptium. Etude thérapeutique réalisée au Sénégal
La N.M.H.E. chef de file d'une nouvelle serie chimique est un agent cytotoxique agissant par interaction au niveau de l'ADN. Les… 
1983
1983
Human and rat urinary metabolites of the antitumor drug Celiptium (N2-methyl-9-hydroxyellipticinium acetate, NSC 264137). Identification of cysteine conjugates supporting the "biooxidative alkylation…
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