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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
- E. Lefrançais, S. Roga, +4 authors C. Cayrol
- Biology, MedicineProceedings of the National Academy of Sciences
- 17 January 2012
It is proposed that the inflammatory microenvironment may exacerbate disease-associated functions of IL-33 through the generation of highly active mature forms, which are produced by activated human neutrophils ex vivo, are biologically active in vivo, and have a ∼10-fold higher activity than full-length IL- 33 in cellular assays.
Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation.
- T. Cresteil, B. Monsarrat, P. Alvinerie, J. Treluyer, I. Vieira, M. Wright
- Biology, MedicineCancer research
- 15 January 1994
Microsomes from patients treated with barbiturates and benzodiazepines increased the formation of metabolite M4 to the level of metabolites M5, demonstrating that drug interactions could modify the human metabolism of taxol.
Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells.
The ATPase and helicase activities of Prp43p are stimulated by the G‐patch protein Pfa1p during yeast ribosome biogenesis
The results strongly suggest that stimulation of ATPase/helicase activities of Prp43p by Pfa1p is required for efficient 20S pre‐rRNA‐to‐18S rRNA conversion.
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition
- S. Dutertre, M. Cazales, +10 authors B. Ducommun
- Biology, MedicineJournal of Cell Science
- 15 May 2004
It is demonstrated that the CDC25B phosphatase, an activator of cyclin dependent kinases at mitosis, is phosphorylated both in vitro and in vivo by Aurora-A on serine 353 and that this phosphorylation form ofCDC25B is located at the centrosome during mitosis.
The Splicing ATPase Prp43p Is a Component of Multiple Preribosomal Particles
- S. Lebaron, C. Froment, +4 authors Y. Henry
- Medicine, BiologyMolecular and Cellular Biology
- 1 November 2005
It is found that depletion of Prp43p leads to accumulation of 35S pre-rRNA and strongly reduces levels of all downstream pre- rRNA processing intermediates, and the steady-state levels of mature rRNAs are greatly diminished following Prp 43p depletion.
Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins[S]
It is observed that the exosomes were internalized by resting and activated RBL cells and that they accumulated in an endosomal compartment, indicating that exosome are carriers of GTP-activatable phospholipases and lipid mediators from cell to cell.
Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship.
- T. Cresteil, B. Monsarrat, J. Dubois, M. Sonnier, P. Alvinerie, F. Guéritte
- Chemistry, MedicineDrug metabolism and disposition: the biological…
- 1 April 2002
Data strongly suggested that the structure of the lateral chain and the nature of substituent in position 10 play an important role in determining the regioselective oxidation by P450 proteins and modulate the reaction rate by human liver microsomes.
The THAP-Zinc Finger Protein THAP1 Associates with Coactivator HCF-1 and O-GlcNAc Transferase
- R. Mazars, Anne Gonzalez-de-Peredo, +10 authors J. Girard
- Biology, MedicineThe Journal of Biological Chemistry
- 3 March 2010
It is reported that THAP1 shares sequence characteristics, in vivo expression patterns and protein partners with THAP3, another THAP-zf protein, and that HCF-1 is essential for transcriptional activation of RRM1.