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Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.
Alkane hydroxylation proceeds by TSR,70-72,120 in which the HS mechanism is truly stepwise with a finite lifetime for the radical intermediate, whereas the LS mechanism is effectively concerted with an ultrashort lifetime forThe radical intermediate.
Metal-Oxo and Metal-Peroxo Species in Catalytic Oxidations
B. Meunier, J. Bernadou: Active Iron-Oxo and Iron-Peroxo Species in Cytochrome P-450 and Peroxidases Oxo-Hydroxo Tautomerism with Water-Soluble Metalloporphyrins .- D.L. Wertz, J.S. Valentine:
Trioxaquines Are New Antimalarial Agents Active on All Erythrocytic Forms, Including Gametocytes
The present study confirms the absence of toxicity of this trioxaquine DU1302 on cell lines and in a mice model and exhibits potent activity against gametocytes, the form transmitted by mosquitoes, as killing of the gametocyte is essential to limit the spread of malaria.
Potassium monopersulfate and a water-soluble manganese porphyrin complex, [Mn(TMPyP)](OAc)5, as an efficient reagent for the oxidative cleavage of DNA.
The high cleavage activity of the monopersulfate-manganese porphyrin system makes it a good candidate for DNA-footprinting experiments and an efficient reagent for the oxidative cleavage of DNA.
The antimalarial drug artemisinin alkylates heme in infected mice.
The identification of heme-artemisinin adducts in mice should be considered as the signature of the alkylation capacity of art Artemisinin in vivo.
Selection of a trioxaquine as an antimalarial drug candidate
One of these molecules, PA1103/SAR116242, is highly active in vitro on several sensitive and resistant strains of Plasmodium falciparum and combined with a good drug profile (preliminary absorption, metabolism, and safety parameters), these data were favorable for the selection of this particular trioxaquine for development as drug candidate.
In Vitro Activities of DU-1102, a New Trioxaquine Derivative, against Plasmodium falciparum Isolates
The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates of Plasmodium falciparum, suggesting an independent mode of action of the trioxquine against the parasites.
Biomimetic oxidations catalyzed by transition metal complexes
Thermodynamic influences of C-H bond oxidation, J.M. Mayer distinguishing biomimetic oxidations from oxidations mediated by freely diffusing radicals, K.U. Ingold, P.A. MacFaul biomimetic