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Catalytic Domain

Known as: Regions, Catalytic, Core, Catalytic, Catalytic Domains 
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
National Institutes of Health

Related topics

Related topics

2 relations
aspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Targeting the PI3K pathway in cancer: are we making headway?
The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated pathways in cancer and, consequently, more than 40 compounds… Expand
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Review
2017
Review
2017
NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease
Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme complex with the sole function of producing… Expand
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Review
2017
Review
2017
ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non–Small Cell Lung Cancer
Introduction: Chromosomal rearrangements involving the gene ROS1 define a distinct molecular subset of NSCLCs with sensitivity to… Expand
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Review
2016
Review
2016
Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets
Proteolytic enzymes are crucial for a variety of biological processes in organisms ranging from lower (virus, bacteria, and… Expand
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Review
2016
Review
2016
HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases
Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have enormous therapeutic potential and have… Expand
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Review
2015
Review
2015
A historical overview of protein kinases and their targeted small molecule inhibitors.
Protein kinases play a predominant regulatory role in nearly every aspect of cell biology and they can modify the function of a… Expand
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Review
1995
Review
1995
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase… Expand
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Highly Cited
1995
Highly Cited
1995
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.
Focal adhesion kinase (FAK) is a widely expressed nonreceptor protein-tyrosine kinase implicated in integrin-mediated signal… Expand
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Highly Cited
1991
Highly Cited
1991
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members.
Publisher Summary To help cope with the rapidly expanding protein kinase family, a database of the catalytic domain amino acid… Expand
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Review
1988
Review
1988
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not… Expand
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