Catalytic Domain

Known as: Regions, Catalytic, Core, Catalytic, Catalytic Domains 
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
010203019772017

Papers overview

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2011
2011
BACKGROUND Colorectal cancer (CRC) is one of the most common malignancies but the current therapeutic approaches for advanced CRC… (More)
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2010
2010
The metabolic regulator AMP-activated protein kinase (AMPK) maintains cellular homeostasis through regulation of proteins… (More)
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Highly Cited
2009
Highly Cited
2009
Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors… (More)
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2007
2007
p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a… (More)
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2006
2006
Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but… (More)
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Highly Cited
2003
Highly Cited
2003
Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike… (More)
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2001
2001
We have determined X-ray crystal structures with up to 1.5 Å resolution of the catalytic domain of death-associated protein… (More)
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1998
1998
Cdc25 phosphatases activate the cell division kinases throughout the cell cycle. The 2.3 A structure of the human Cdc25A… (More)
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Highly Cited
1997
Highly Cited
1997
Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal human somatic cells but is reactivated… (More)
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1997
1997
HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenzae. The isolated C-terminal… (More)
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