FAQ

Catalytic Domain

Known as: Regions, Catalytic, Core, Catalytic, Catalytic Domains 
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
010203019772017

Related topics

Related topics

2 relations
aspects of radiation effectsphysiological aspects

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Catalytic Domain
physiological aspects
aspects of radiation effects

Papers overview

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2011
2011
Overexpression of Nuclear Protein Kinase CK2 α Catalytic Subunit (CK2α) as a Poor Prognosticator in Human Colorectal Cancer
BACKGROUND Colorectal cancer (CRC) is one of the most common malignancies but the current therapeutic approaches for advanced CRC… (More)
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2010
2010
Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase
The metabolic regulator AMP-activated protein kinase (AMPK) maintains cellular homeostasis through regulation of proteins… (More)
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Highly Cited
2009
Highly Cited
2009
Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment
Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors… (More)
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2007
2007
Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs
p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a… (More)
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2006
2006
trt-1 Is the Caenorhabditis elegans Catalytic Subunit of Telomerase
Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but… (More)
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Highly Cited
2003
Highly Cited
2003
Structure of the Catalytic Domain of Human DOT1L, a Non-SET Domain Nucleosomal Histone Methyltransferase
Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike… (More)
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2001
2001
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression
We have determined X-ray crystal structures with up to 1.5 Å resolution of the catalytic domain of death-associated protein… (More)
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1998
1998
Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A
Cdc25 phosphatases activate the cell division kinases throughout the cell cycle. The 2.3 A structure of the human Cdc25A… (More)
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Highly Cited
1997
Highly Cited
1997
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal human somatic cells but is reactivated… (More)
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1997
1997
Molecular Organization in Site-Specific Recombination: The Catalytic Domain of Bacteriophage HP1 Integrase at 2.7 Ã… Resolution
HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenzae. The isolated C-terminal… (More)
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