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Catalytic Domain

Known as: Regions, Catalytic, Core, Catalytic, Catalytic Domains 
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
National Institutes of Health

Papers overview

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Review
2018
Review
2018
The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated pathways in cancer and, consequently, more than 40 compounds… Expand
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Review
2017
Review
2017
Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme complex with the sole function of producing… Expand
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Review
2017
Review
2017
Introduction: Chromosomal rearrangements involving the gene ROS1 define a distinct molecular subset of NSCLCs with sensitivity to… Expand
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Review
2016
Review
2016
Proteolytic enzymes are crucial for a variety of biological processes in organisms ranging from lower (virus, bacteria, and… Expand
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Review
2016
Review
2016
Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have enormous therapeutic potential and have… Expand
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Review
2015
Review
2015
Protein kinases play a predominant regulatory role in nearly every aspect of cell biology and they can modify the function of a… Expand
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Review
1995
Review
1995
The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase… Expand
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Highly Cited
1995
Highly Cited
1995
Focal adhesion kinase (FAK) is a widely expressed nonreceptor protein-tyrosine kinase implicated in integrin-mediated signal… Expand
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Highly Cited
1991
Highly Cited
1991
Publisher Summary To help cope with the rapidly expanding protein kinase family, a database of the catalytic domain amino acid… Expand
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Review
1988
Review
1988
In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not… Expand
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