Parameters of helix–coil transition theory for alanine‐based peptides of varying chain lengths in water
- J. M. Scholtz, H. Qian, E. York, J. Stewart, R. L. Baldwin
- ChemistryBiopolymers
- 1 November 1991
The success of helix–coil theory in describing the unfolding transitions of short peptides in water indicates that helical propensities, or s values, can be determined from substitution experiments in short alanine‐based peptides.
Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.
- L. Steranka, D. Manning, S. Snyder
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 May 1988
Results indicate that bradykinin is a physiologic mediator of pain and that bradaykinin antagonists have analgesic activity in both acute and chronic pain models.
Solid Phase Peptide Synthesis
- J. Stewart
- Chemistry, Biology
- 1 June 1984
This work has shown that effective methods of peptide synthesis are crucial to progress in this area, because only by synthesis can adequate amounts of important peptides be made available for chemical, biologi...
Calorimetric determination of the enthalpy change for the alpha-helix to coil transition of an alanine peptide in water.
- J. M. Scholtz, S. Marqusee, D. W. Bolen
- ChemistryProceedings of the National Academy of Sciences…
- 1 April 1991
The enthalpy change (delta H) accompanying the alpha-helix to random coil transition in water has been determined calorimetrically for a 50-residue peptide of defined sequence that contains primarily alanine, and it is suggested that the side chain has little effect on delta H.
Competitive antagonists of bradykinin
- R. Vavrek, J. Stewart
- Biology, ChemistryPeptides
- 1 March 1985
Urea unfolding of peptide helices as a model for interpreting protein unfolding.
- J. M. Scholtz, D. Barrick, E. York, J. Stewart, R. L. Baldwin
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 3 January 1995
The result indicates that the interaction between urea and peptide groups accounts for a major part of the denaturing action of urea on proteins, as predicted earlier by some model studies with small molecules.
Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs.
- W. Shen, M. Lundborg, T. Hintze
- Medicine, BiologyJournal of applied physiology
- 1 July 1994
The results suggest that whereas EDRF functions to regulate basal vascular tone and vascular resistance during exercise, EDRf has a minor role in determining the pattern of the redistribution of tissue blood flow during exercise.
Kinetics of amide proton exchange in helical peptides of varying chain lengths. Interpretation by the Lifson-Roig equation.
- C. Rohl, J. M. Scholtz, E. York, J. Stewart, R. L. Baldwin
- PhysicsBiochemistry
- 11 February 1992
The kinetics of amide proton exchange (1H----2H) have been measured by proton nuclear magnetic resonance spectroscopy for a set of helical peptides with the generic formula Ac-(AAKAA)m Y-NH2 and with…
Bradykinin antagonists: Development and applications
- J. Stewart
- ChemistryBiopolymers
- 1995
Principal points in the history of the kallikrein–kinin field and of kinin biology are reviewed and the chemistry and development of antagonists for B1 and B2 kinin receptors is discussed.
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