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Parameters of helix–coil transition theory for alanine‐based peptides of varying chain lengths in water
The success of helix–coil theory in describing the unfolding transitions of short peptides in water indicates that helical propensities, or s values, can be determined from substitution experiments in short alanine‐based peptides. Expand
Solid Phase Peptide Synthesis
Abstract The last two decades have been an era of rapid progress in peptide research. This era was begun by the work of Sanger on the amino acid sequence determination of insulin and by du VigneaudExpand
Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.
Results indicate that bradykinin is a physiologic mediator of pain and that bradaykinin antagonists have analgesic activity in both acute and chronic pain models. Expand
Calorimetric determination of the enthalpy change for the alpha-helix to coil transition of an alanine peptide in water.
The enthalpy change (delta H) accompanying the alpha-helix to random coil transition in water has been determined calorimetrically for a 50-residue peptide of defined sequence that contains primarily alanine, and it is suggested that the side chain has little effect on delta H. Expand
Urea unfolding of peptide helices as a model for interpreting protein unfolding.
The result indicates that the interaction between urea and peptide groups accounts for a major part of the denaturing action of urea on proteins, as predicted earlier by some model studies with small molecules. Expand
Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs.
The results suggest that whereas EDRF functions to regulate basal vascular tone and vascular resistance during exercise, EDRf has a minor role in determining the pattern of the redistribution of tissue blood flow during exercise. Expand
Bradykinin antagonists: Development and applications
Principal points in the history of the kallikrein–kinin field and of kinin biology are reviewed and the chemistry and development of antagonists for B1 and B2 kinin receptors is discussed. Expand
Kinetics of amide proton exchange in helical peptides of varying chain lengths. Interpretation by the Lifson-Roig equation.
The kinetics of amide proton exchange (1H----2H) have been measured by proton nuclear magnetic resonance spectroscopy for a set of helical peptides with the generic formula Ac-(AAKAA)m Y-NH2 and withExpand
Modulation of isolation-induced fighting by N- and C-terminal analogs of substance P: Evidence for multiple recognition sites
The results demonstrate that a behavioral effect of SP may be duplicated by an N-terminal fragment of the SP molecule, and that peptide fragments or analogs of the N- and C-Terminal portions of theSP molecule can exert opposing effects on a specific behavior. Expand
Competitive antagonists of bradykinin
The first sequence-related competitive inhibitors of the classic kinin in vitro (rat uterus guinea pig ileum) and in vivo (rat blood pressure) assays have been developed. Replacement of the prolineExpand