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Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus.
  • E. Miyamoto
  • Biology, Medicine
  • Journal of pharmacological sciences
  • 2006
TLDR
The results suggest that LTP induction and maintenance would be models of short- and long-term memory, respectively. Expand
Activation of Akt/Protein Kinase B Contributes to Induction of Ischemic Tolerance in the CA1 Subfield of Gerbil Hippocampus
TLDR
The results suggest that Akt activation is induced by a sublethal ischemic insult in gerbil hippocampus and contributes to neuroprotective isChemic tolerance in CA1 pyramidal neurons. Expand
Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.
TLDR
It is reported that high, but not low frequency stimulation applied to two groups of CA1 afferents resulted in a long lasting increase in the Ca(2+)-independent and total activities of the enzyme as well as an increased in the ratio of Ca( 2+)- independent to total activity. Expand
Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A.
TLDR
It is shown here that a phosphoprotein encoded by mouse alpha4 (malpha4) gene transmitting a signal through B-cell antigen receptor (BCR) is associated with the catalytic subunit of protein phosphatase 2A (PP2Ac). Expand
Dephosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin by Calcineurin
TLDR
The results suggest that calcineurin plays an important role in the functions of microtubules via dephosphorylation, and not in a site‐specific manner as previously suggested. Expand
Activation of Mitogen‐Activated Protein Kinase in Cultured Rat Hippocampal Neurons by Stimulation of Glutamate Receptors
TLDR
The observations suggest that MAP kinase activation through glutamate receptors in hippocampal neurons is mediated by both the PKC‐dependent and the Ca2+‐dependent pathways and that the activation of Raf‐1 is not involved. Expand
CaM KINASE II IN LONG-TERM POTENTIATION
TLDR
The idea that CaM kinase II contributes to the induction of hippocampal LTP in both postsynaptic and presynaptic regions through phosphorylation of target proteins such as the AMPA receptor, MAP2 and synapsin I is supported. Expand
Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments.
TLDR
The results suggest that the phosphorylation of each site in tau differs among the maturing stages of neurofibrillary change and that abnormal phosphorylated tau in the neuronal soma occurs at 199, 202, 409 and 422 earlier than at threonine 231 and serine 396. Expand
Activation of Ca2+/calmodulin-dependent protein kinase II and protein kinase C by glutamate in cultured rat hippocampal neurons.
TLDR
It is suggested that glutamate can activate CaM kinase II through the ionotropic NMDA receptor, which in turn increases the phosphorylation of microtuble-associated protein 2 and synapsin I. Expand
Staurosporine: An Effective Inhibitor for Ca2+/Calmodulin‐Dependent Protein Kinase II
TLDR
It is suggested that staurosporine inhibits CaM kinase II by interacting with the catalytic domain, distinct from the ATP‐binding site or substrate‐ binding site, of the enzyme and that Staurospora is an effective inhibitor for CaM Kinase II in the cell system. Expand
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