Caspases, Effector

Known as: Caspases, Effector [Chemical/Ingredient], Effector Caspases 
A subclass of caspases that contain short pro-domain regions. They are activated by the proteolytic action of INITIATOR CASPASES. Once activated they… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP… (More)
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Highly Cited
2008
Highly Cited
2008
Ubiquitin-mediated inactivation of caspases has long been postulated to contribute to the regulation of apoptosis. However… (More)
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Highly Cited
2006
Highly Cited
2006
The current model of apoptosis holds that upstream signals lead to activation of downstream effector caspases. We generated mice… (More)
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Highly Cited
2005
Highly Cited
2005
Some members of the inhibitor of apoptosis (IAP) family suppress apoptosis by neutralizing caspases. The current model suggests… (More)
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Highly Cited
2005
Highly Cited
2005
We tested the effects of small-molecule XIAP antagonists based on a polyphenylurea pharmacophore on cultured acute myelogenous… (More)
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Highly Cited
2004
Highly Cited
2004
Achieving proper organ size requires a balance between proliferation and cell death. For example, at least 40%-60% of cells in… (More)
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Review
2004
Review
2004
Caspases are the central component of the apoptotic machinery that irreversibly commits a cell to die. Whereas all caspases are… (More)
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Highly Cited
2003
Highly Cited
2003
Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly… (More)
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Review
2000
Review
2000
Caspases are a large family of evolutionarily conserved proteases found from Caenorhabditis elegans to humans. Although the first… (More)
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Highly Cited
1999
Highly Cited
1999
In mammals, apoptotic protease-activating factor 1 (Apaf-1), cytochrome c, and dATP activate caspase-9, which initiates the… (More)
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