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Caspases, Effector

Known as: Caspases, Effector [Chemical/Ingredient], Effector Caspases 
A subclass of caspases that contain short pro-domain regions. They are activated by the proteolytic action of INITIATOR CASPASES. Once activated they… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Programmed cell death (PCD) is probably the most widely discussed subject among the topics of cancer therapy. Over the last 2… Expand
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Highly Cited
2010
Highly Cited
2010
Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP… Expand
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Review
2004
Review
2004
Caspases are the central component of the apoptotic machinery that irreversibly commits a cell to die. Whereas all caspases are… Expand
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Highly Cited
2003
Highly Cited
2003
Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly… Expand
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Review
2001
Review
2001
Cellular stresses, such as growth factor deprivation, DNA damage or oncogene expression, lead to stabilization and activation of… Expand
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Review
2000
Review
2000
  • H. Chang, X. Yang
  • Microbiology and Molecular Biology Reviews
  • 2000
  • Corpus ID: 7667541
SUMMARY Caspases are a large family of evolutionarily conserved proteases found from Caenorhabditis elegans to humans. Although… Expand
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Highly Cited
2000
Highly Cited
2000
Caspases have been strongly implicated to play an essential role in apoptosis. A critical question regarding the role(s) of these… Expand
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Highly Cited
2000
Highly Cited
2000
Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and promotes cytochrome c… Expand
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Highly Cited
2000
Highly Cited
2000
Apoptosis is an ordered cascade of enzymatic events that culminates in cell death and the cleavage of DNA into characteristic… Expand
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Highly Cited
1998
Highly Cited
1998
Caspases plays a key role in the execution phase of apoptosis. “Initiator” caspases, such as caspase-8, activate “effector… Expand
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