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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
The data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells as well as an extraordinary marker for cells that express E-cadherin but lack expression of Vimentin. Expand
Two CD95 (APO‐1/Fas) signaling pathways
In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells). Expand
Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.
The data suggest that in vivo CAP1–4 are the APO‐1 apoptosis‐transducing molecules. Expand
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
A large number of the subjects studied had previously been diagnosed with central giant cell granuloma, a type of cancer which can be difficult to treat with conventional chemotherapy. Expand
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
This work utilized nano-electrospray tandem mass spectrometry to identify CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling complex, and found a novel 55 kDa protein, designated FLICE, which has homology to both FADD and the ICE/CED-3 family of cysteine proteases. Expand
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
A functional classification of cell death subroutines is proposed that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic programmed cell death, regulated necrosis, autophagic cell death and mitotic catastrophe. Expand
The CD95(APO-1/Fas) DISC and beyond
A number of proteins have been reported to regulate formation or activity of the DISC, the complex of proteins that forms upon triggering of CD95 that is essential for induction of apoptosis. Expand
FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)
The data indicate that FLICE is the first in a cascade of ICE‐like proteases activated by CD95 and that this activation requires a functional CD95 DISC. Expand
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
A new family of viral inhibitors (v-FLIPs) which interfere with apoptosis signalled through death receptors3 and which are present in several γ-herpesviruses (including Kaposi's-sarcoma-associated human herpesvirus-8), as well as in the tumorigenic human molluscipoxvirus4. Expand
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
It is shown that primary human omental adipocytes promote homing, migration and invasion of ovarian cancer cells, and that adipokines including interleukin-8 (IL-8) mediate these activities, and adipocytes provide fatty acids for rapid tumor growth. Expand