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Caspases, Effector

Known as: Caspases, Effector [Chemical/Ingredient], Effector Caspases 
A subclass of caspases that contain short pro-domain regions. They are activated by the proteolytic action of INITIATOR CASPASES. Once activated they… 
National Institutes of Health

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In BloodProcess of secretionaspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Programmed Cell Death, from a Cancer Perspective: An Overview
Programmed cell death (PCD) is probably the most widely discussed subject among the topics of cancer therapy. Over the last 2… 
Highly Cited
2005
Highly Cited
2005
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
We tested the effects of small-molecule XIAP antagonists based on a polyphenylurea pharmacophore on cultured acute myelogenous… 
Highly Cited
2005
Highly Cited
2005
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
Some members of the inhibitor of apoptosis (IAP) family suppress apoptosis by neutralizing caspases. The current model suggests… 
2005
2005
Caspase-9 and effector caspases have sequential and distinct effects on mitochondria
Proapoptotic Bcl-2 family members alter mitochondrial permeability resulting in the release of apoptogenic factors that initiate… 
Review
2004
Review
2004
Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology.
Highly Cited
2003
Highly Cited
2003
Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS.
Highly Cited
2003
Highly Cited
2003
Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.
The inhibitor of apoptosis proteins (IAPs) plays a central role in repressing caspase-mediated cell death. However, little is… 
Highly Cited
2000
Highly Cited
2000
Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality*
Caspases have been strongly implicated to play an essential role in apoptosis. A critical question regarding the role(s) of these… 
Highly Cited
2000
Highly Cited
2000
The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis.
Ectopic overexpression of Apaf-1 (2.5-fold) in human acute myelogenous leukemia HL-60 cells (HL-60/Apaf-1 cells) induced… 
Review
1999
Review
1999
Apoptosis: checkpoint at the mitochondrial frontier.
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