Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone

Known as: Propanedinitrile, ((4-(trifluoromethoxy)phenyl)hydrazono)-, FCCP, Carbonyl Cyanide para-Trifluoromethoxyphenylhydrazone 
A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.
National Institutes of Health

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In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Broader (1)

Proton Ionophores

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Highly Cited
2013
Highly Cited
2013
2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.
WRITING COMMITTEE MEMBERS Clyde W. Yancy, MD, MSc, FACC, FAHA, Chairyz; Mariell Jessup, MD, FACC, FAHA, Vice Chair*y; Biykem… (More)
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Highly Cited
2009
Highly Cited
2009
ACCF/AHA Expert Consensus Document
WRITING COMMITTEE MEMBERS Vallerie V. McLaughlin, MD, FACC, FAHA, FCCP, Chair*; Stephen L. Archer, MD, FACC, FAHA†; David B… (More)
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Review
2009
Review
2009
Lipid peroxidation: physiological levels and dual biological effects.
Lipid peroxidation (LPO) has been shown to induce disturbance of membrane organization and functional loss and modification of… (More)
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Highly Cited
2001
Highly Cited
2001
Geometric nomenclature and classification of RNA base pairs.
Non-Watson-Crick base pairs mediate specific interactions responsible for RNA-RNA self-assembly and RNA-protein recognition. An… (More)
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Highly Cited
2000
Highly Cited
2000
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia… (More)
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Highly Cited
1997
Highly Cited
1997
JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis.
The sensitivity and specificity of three fluorescent probes used for cytofluorimetric analysis of mitochondrial membrane… (More)
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Highly Cited
1997
Highly Cited
1997
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
There is increasing evidence for a central role in mammalian apoptosis of the interleukin-1 beta-converting enzyme (ICE) family… (More)
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Highly Cited
1990
Highly Cited
1990
A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.
Interleukin 1 (IL-1) is a major soluble mediator of inflammation. Two human IL-1 genes, alpha and beta, have been isolated, which… (More)
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1982
1982
Restoration of membrane potential in mitochondria deenergized with carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP).
The membrane potential (delta psi) of rat liver mitochondria dropped upon addition of carbonyl cyanide p… (More)
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Highly Cited
1980
Highly Cited
1980
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.
Submitochondrial particles from bovine heart in which NADH dehydrogenase is reduced by either addition of NADH and rotenone or by… (More)
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