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The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
Loss of p16 functional activity leading to disruption of the p16/cyclin-dependent kinase (CDK) 4:cyclin D/retinoblastoma pathway is the most common event in human tumorigenesis, suggesting thatExpand
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Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.
A new series of estradiol analogs was synthesized in an attempt to improve on the anticancer activity of 2-methoxyestradiol, a naturally occurring mammalian tubulin polymerization inhibitor. TheExpand
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Evaluation of dimethyl sulfoxide as a solvent in pharmacological experiments.
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Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy.
INTRODUCTION Chronic hyperglycaemia in type 2 diabetes, effects the central nervous system by altering the concentrations of brain metabolites like N-acetyl aspartate (NAA) and myoinositol (mI),Expand
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Low-level beta activity measurement of solid samples using plastic scintillator anticoincidence
Abstract An instrument consisting of a G.M. counter shieded by a plastic-scintillator-cone and 15 cm of lead has been designed giving a background of 12 counts per hour. The sample spread in an areaExpand
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Supernumerary tooth in palate--a case report.
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Specific reduction of E prostaglandins to F.alpha. prostaglandins and prostaglandin E2 to prostaglandin E1
This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structuresExpand
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