• Publications
  • Influence
Sodium/calcium exchange: its physiological implications.
TLDR
In cardiac myocytes, and probably other cell types, the exchanger serves a housekeeping role by maintaining a low intracellular Ca2+ concentration; its possible role in cardiac excitation-contraction coupling is controversial.
The influence of calcium on sodium efflux in squid axons
1. Previous work has shown that the sodium efflux from the axons of Loligo forbesi increases when external sodium is replaced by lithium.
Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.
  • M. Blaustein
  • Chemistry, Medicine
    The American journal of physiology
  • 1 May 1977
TLDR
The cellular mechanisms which may account for the well-documented correlation between sodium metabolism and peripheral vascular resistance are elucidated and the evidence that the Na electrochemical gradient across the sarcolemma plays an important role in cell calcium regulation is reviewed.
Identification and characterization of a ouabain-like compound from human plasma.
TLDR
An endogenous substance from human plasma is purified and structurally identified by mass spectroscopy that binds with high affinity to this receptor and that is indistinguishable from the cardenolide ouabain.
Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells.
TLDR
Three isoforms (alpha1, alpha2, and alpha3) of the catalytic (alpha) subunit of the plasma membrane (PM) Na+ pump have been identified in the tissues of birds and mammals, and high resolution immunocytochemical techniques were employed to localize alpha subunit isoforms in primary cultured rat astrocytes, neurons, and arterial myocytes.
Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.
  • M. Blaustein
  • Chemistry, Medicine
    The Journal of physiology
  • 1 June 1975
TLDR
The results indicate that synaptosomes may increase their permeability to Ca, accumulate Ca and release neural transmitter substances, when stimulated by depolarizing agents under appropriate physiological conditions.
Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes.
TLDR
The hypoxia-induced inhibition of Iout in PA cells was accompanied by an apparent increase in inward Ca2+ current, and some of the channels responsible for this current may be open at the resting membrane potential of PA cells used in this study.
Spatially and Functionally Distinct Ca2+ Stores in Sarcoplasmic and Endoplasmic Reticulum
TLDR
The results suggest that cells can generate spatially and temporally distinct calcium signals to control individual calcium-dependent processes.
Effects of internal and external cations and of ATP on sodium-calcium and calcium-calcium exchange in squid axons.
TLDR
ATP increases the affinity of the transport mechanism for both Cai and Nao, but it does not affect the maximal transport rate at saturating [Ca2+]i and [Na+]o; this suggest that ATP may be acting as a catalyst of modulator, and not as an energy source.
Physiological effects of endogenous ouabain: control of intracellular Ca2+ stores and cell responsiveness.
  • M. Blaustein
  • Chemistry, Medicine
    The American journal of physiology
  • 1 June 1993
TLDR
Evidence is examined that endogenous ouabain may play a role in numerous physiological and pathophysiological processes associated with altered fluid and electrolyte metabolism and deviations from the normal blood pressure-blood volume relationship.
...
1
2
3
4
5
...