• Publications
  • Influence
Sodium/calcium exchange: its physiological implications.
The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ pump. As aExpand
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The influence of calcium on sodium efflux in squid axons.
1. Previous work has shown that the sodium efflux from the axons of Loligo forbesi increases when external sodium is replaced by lithium.2. The increase in efflux in lithium was unaffected by ouabainExpand
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Identification and characterization of a ouabain-like compound from human plasma.
The plasma membrane sodium-potassium pumps that regulate intracellular sodium in most animal cells have specific, high-affinity receptors for the digitalis glycosides and their aglycones. This hasExpand
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Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.
  • M. Blaustein
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 May 1977
An attempt is made to elucidate the cellular mechanisms which may account for the well-documented correlation between sodium metabolism and peripheral vascular resistance. As a starting point, theExpand
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Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.
  • M. Blaustein
  • Medicine, Chemistry
  • The Journal of physiology
  • 1 June 1975
1. 45-Ca uptake by pinched-off nerve terminals (synaptosomes) of rat brain incubated in standard physiological saline (including 132 mM-Na + 5mM-K + 1-2 mM-Ca) at 30 degrees C averages about 0-5Expand
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Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes.
To explore possible mechanisms underlying hypoxia-induced pulmonary vasoconstriction, the effect of hypoxia on outward K+ current (Iout) was evaluated in primary cultured rat pulmonary (PA) andExpand
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Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells.
Three isoforms (alpha1, alpha2, and alpha3) of the catalytic (alpha) subunit of the plasma membrane (PM) Na+ pump have been identified in the tissues of birds and mammals. These isoforms differ inExpand
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Spatially and Functionally Distinct Ca2+ Stores in Sarcoplasmic and Endoplasmic Reticulum
The organization of calcium (Ca2+) stores in the sarcoplasmic and endoplasmic reticulum (S-ER) is poorly understood. The dynamics of the storage and release of calcium in the S-ER of intact, culturedExpand
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Physiological effects of endogenous ouabain: control of intracellular Ca2+ stores and cell responsiveness.
  • M. Blaustein
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 June 1993
Ouabain is a well-known compound but a newly discovered adrenal cortical hormone that plays a role in cell Na+ regulation and in whole body salt and water balance. Ouabain may also be a paracrineExpand
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Effects of internal and external cations and of ATP on sodium-calcium and calcium-calcium exchange in squid axons.
Calcium-45 efflux was measured in squid axons whose internal solute concentration was controlled by internal dialysis. Most of the Ca efflux requires either external Na (Na-Ca exchange) or externalExpand
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