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Cancer/Testis Antigen 2

Known as: LAGE-1, Autoimmunogenic Cancer/Testis Antigen NY-ESO-2, CT6.2 
Cancer/testis antigen 2 (210 aa, ~21 kDa) is encoded by the human CTAG2 gene. This protein may play a role in tumorigenesis of several tissues.
National Institutes of Health

Related topics

Related topics

4 relations
CTAG2 geneCancer Promoting GenesMetastasis InductionNeoplastic Cell Transformation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT
Meeting abstracts We report on a 26 patient phase I/II clinical trial ([NCT01352286][1]) to investigate the safety, feasibility… 
2012
2012
Adoptive Transfer of Gene-Modified T-Cells Engineered to Express High-Affinity TCRs for Cancer-Testis Antigens (CTAs) NY-ESO-1 or Lage-1, in MM Patients Post Auto-SCT
Abstract 472 Background: Despite recent therapeutic advances, multiple myeloma (MM) remains primarily an incurable cancer… 
2011
2011
The therapeutic efficacy of LAGE-1 DNA tumor vaccine to the tumor
  • X. Yi
  • 2011
  • Corpus ID: 87571904
pcDNA3.1/LAGE-1 eukaryotic expression vector was constructed and transfected into EMT6 cells;BalB/c mice were divided into 4… 
2009
2009
Expression of Cancer Testis (CT) Antigens NY-ESO-1 and LAGE-1 in Multiple Myeloma (MM): Could a Vaccine against the Former Antigen Be Effective against the Latter?
Abstract 4887 Introduction In recent years, the expression of CT antigens has been studied in various malignant neoplasias. Based… 
2006
2006
Frequent Expression of Cancer/Testis Antigens CT7 and LAGE-1 in Advanced Stage Multiple Myeloma: Are They Possible Targets for Immunotherapy?.
Introduction: Recently, Jungbluth and collaborators (Blood 2005;106(1):167) demonstrated that CT7 and MAGE-A3/6 are frequently… 
2006
2006
A New Specific Gene Expression in Squamous Cell Carcinoma of the Esophagus Detected Using Representational Difference Analysis and cDNA Microarray
Objectives: To detect new specific gene expressions in squamous cell carcinoma of the esophagus. Methods: Representational… 
2004
2004
[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery].
OBJECTIVE To investigate the possibility of utilizing cancer-testi (CT) antigens as targets for immunotherapy of non-small cell… 
2003
2003
Targets for Immunotherapy in Epithelial Ovarian Cancer NY-ESO-1 and LAGE-1 Cancer-Testis Antigens Are Potential
Cancer-testis (CT) antigens are expressed in a variety of cancers, but not in normal adult tissues, except for germ cells of the… 
Review
2002
Review
2002
Towards Defining Specific Antigens for Cutaneous Lymphomas
Cutaneous lymphomas (CLs) are a heterogeneous group of malignancies of T-cell (cutaneous T-cell lymphoma, CTCL) or B-cell… 
Highly Cited
2001
Highly Cited
2001
Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas
Cancer-testis antigens (CTAs) such as MAGE are selectively expressed in various types of human neoplasms but not in normal… 
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