• Publications
  • Influence
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
TLDR
A unifying conceptual framework called “cancer immunoediting,” which integrates the immune system’s dual host-protective and tumor-promoting roles is discussed. Expand
Cancer immunoediting: from immunosurveillance to tumor escape
TLDR
The historical and experimental basis of cancer immunoediting is summarized and its dual roles in promoting host protection against cancer and facilitating tumor escape from immune destruction are discussed. Expand
The three Es of cancer immunoediting.
TLDR
The history of the cancer immunosurveillance controversy is summarized and its resolution and evolution into the three Es of cancer immunoediting--elimination, equilibrium, and escape are discussed. Expand
An endotoxin-induced serum factor that causes necrosis of tumors.
TLDR
It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages. Expand
Cancer/testis antigens, gametogenesis and cancer
TLDR
CT antigens are being evaluated for their role in oncogenesis — recapitulation of portions of the germline gene-expression programme might contribute characteristic features to the neoplastic phenotype, including immortality, invasiveness, immune evasion, hypomethylation and metastatic capacity. Expand
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
TLDR
It is shown that lymphocytes and IFNγ collaborate to protect against development of carcinogen-induced sarcomas and spontaneous epithelial carcinomas and also to select for tumour cells with reduced immunogenicity, which explains the apparent paradox of tumour formation in immunologically intact individuals. Expand
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
TLDR
It is concluded that intraepithelial CD8+ TILs and a high CD8-/Treg ratio are associated with favorable prognosis in epithelial ovarian cancer. Expand
The immunobiology of cancer immunosurveillance and immunoediting.
TLDR
The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers. Expand
A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening.
TLDR
R reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma, which indicates that it belongs to an expanding family of immunogenic testicular antigens. Expand
The cancer/testis genes: review, standardization, and commentary.
TLDR
A CT gene database was created to standardize CT nomenclature and accumulate relevant data regarding their expression profiles, immunogenicity, function (where known), gene structure and location, and orthologous groups. Expand
...
1
2
3
4
5
...