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Canavan Disease
Known as:
Disease, Canavan
, Leukodystrophy, Spongiform
, ASPA DEFICIENCY
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A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy…
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National Institutes of Health
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Related topics
Related topics
20 relations
ASPA gene
Aminoacylase 2 Deficiency
Aspartoacylase
Autosomal recessive inheritance
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Narrower (1)
Canavan Disease, Neonatal
Broader (1)
Leukodystrophy
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical…
M. Gerhard-Herman
,
H. Gornik
,
+18 authors
M. E. Walsh
Journal of the American College of Cardiology
2017
Corpus ID: 35160076
Review
2017
Review
2017
2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary
M. Gerhard-Herman
,
H. Gornik
,
+19 authors
J. Halperin
Circulation
2017
Corpus ID: 207696374
Preamble Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific…
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Highly Cited
2012
Highly Cited
2012
Long-Term Follow-Up After Gene Therapy for Canavan Disease
P. Leone
,
D. Shera
,
+12 authors
C. Janson
Science Translational Medicine
2012
Corpus ID: 22151602
Gene therapy for Canavan disease results in a decrease in pathologically elevated N-acetyl-aspartate concentrations in the brain…
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Review
2007
Review
2007
N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
J. Moffett
,
B. Ross
,
P. Arun
,
C. N. Madhavarao
,
A. Namboodiri
Progress in Neurobiology
2007
Corpus ID: 12300449
Highly Cited
2006
Highly Cited
2006
Immune responses to AAV in a phase I study for Canavan disease
S. McPhee
,
C. Janson
,
+8 authors
P. Leone
The journal of gene medicine
2006
Corpus ID: 44408259
Canavan disease is a rare leukodystrophy with no current treatment. rAAV‐ASPA has been developed for gene delivery to the central…
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Highly Cited
2002
Highly Cited
2002
Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain.
C. Janson
,
S. McPhee
,
+17 authors
P. Leone
Human gene therapy
2002
Corpus ID: 21318465
This clinical protocol describes virus-based gene transfer for Canavan disease, a childhood leukodystrophy. Canavan disease, also…
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Review
1995
Review
1995
N-Acetylaspartate in neuropsychiatric disorders
G. Tsai
,
J. Coyle
Progress in Neurobiology
1995
Corpus ID: 35989462
Highly Cited
1993
Highly Cited
1993
Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease
R. Kaul
,
Guang Ping Gao
,
K. Balamurugan
,
R. Matalon
Nature genetics
1993
Corpus ID: 10775138
Canavan disease, an autosomal recessive leukodystrophy, is caused by deficiency of aspartoacylase and accumulation of N…
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Review
1991
Review
1991
A review of chemical issues in 1H NMR spectroscopy: N‐acetyl‐l‐aspartate, creatine and choline
B. Miller
NMR in biomedicine
1991
Corpus ID: 8843464
The structure and function of the chemicals contributing to the three main peaks seen with 1H NMR spectroscopy, N‐acetyl‐L…
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Review
1989
Review
1989
N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain
David L. Birken
,
W. Oldendorf
Neuroscience & Biobehavioral Reviews
1989
Corpus ID: 1478624
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