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Purification, Gene Cloning, Gene Expression, and Mutants of Dps from the Obligate Anaerobe Porphyromonas gingivalis
TLDR
It is demonstrated that P. gingivalis contains a Dps homologue that plays an important role in the protection of cells from peroxide stress, and is regulated by the reactive oxygen species-regulating gene oxyR. Expand
Porphyromonas gingivalis‐induced platelet aggregation in plasma depends on Hgp44 adhesin but not Rgp proteinase
TLDR
Results reveal a novel mechanism of platelet aggregation by P.’gingivalis that depended on Rgp‐, Kgp‐ and haemagglutinin A (HagA)‐encoding genes that intragenically coded for adhesins such as Hgp44. Expand
Construction and characterization of a nonpigmented mutant of Porphyromonas gingivalis: cell surface polysaccharide as an anchorage for gingipains.
TLDR
Results indicate that porR is involved in biosynthesis of cell surface polysaccharide that may function as an anchorage for Rgp, Kgp, haemagglutinins and the haemoglobin receptor protein. Expand
Suppression of Pathogenicity of Porphyromonas gingivalis by Newly Developed Gingipain Inhibitors
TLDR
Results indicate that the newly developed KYT-1 andKYT-36 both should provide a broader application in studies of this important class of enzymes and facilitate the development of new approaches to periodontal diseases. Expand
Role for Gingipains in Porphyromonas gingivalis Traffic to Phagolysosomes and Survival in Human Aortic Endothelial Cells
TLDR
It is found that the number of intracellular viable WT cells decreased more slowly than that of KDP136 cells, thus suggesting that gingipains contribute to bacterial survival, but not to trafficking, within the infected cells. Expand
A Functional Virulence Complex Composed of Gingipains, Adhesins, and Lipopolysaccharide Shows High Affinity to Host Cells and Matrix Proteins and Escapes Recognition by Host Immune Systems
TLDR
Inhibition of the proteolytic activities of the gingipain complex did not up-regulate the cytokine production, indicating that the functional domains in LPS are structurally masked by the complex proteins. Expand
Age-Related Changes in Activities and Localizations of Cathepsins D, E, B, and L in the Rat Brain Tissues
TLDR
The results suggest that the increased levels of cathepsins D, E, and B and the decrease inCathepsin L activity in brain regions of aged rats are related to both the neuronal degeneration and the reactivation of glial cells during the normal aging process of the brain. Expand
Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure.
TLDR
Results indicate that degradation of apoB-100 by Rgp plays a crucial role in the promotion of atherosclerosis by P. gingivalis infection. Expand
Roles for Arg- and Lys-Gingipains in the Disruption of Cytokine Responses and Loss of Viability of Human Endothelial Cells by Porphyromonas gingivalis Infection
TLDR
Findings indicate that P. gingivalis modulates the cytokine response in the cells and disrupts the adhesion activity and the viability through the cooperative action of Rgp and Kgp and thereby may contribute to pathogenesis of cardiovascular diseases as well as periodontal disease. Expand
Association of cathepsin E deficiency with development of atopic dermatitis.
TLDR
It is strongly suggested that the development of AD in cathepsin E-deficient mice is initiated by systemic accumulation of IL-18 and IL-1beta, mainly due to their reduced turnover rates. Expand
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