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ASPA gene

Known as: AMINOACYLASE 2, ASPA, Canavan disease 
National Institutes of Health

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Aspartic Acid
Canavan Disease

Papers overview

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2016
2016
Modeling the Complete Catalytic Cycle of Aspartoacylase.
The complete catalytic cycle of aspartoacylase (ASPA), a zinc-dependent enzyme responsible for cleavage of N-acetyl-l-aspartate… 
2011
2011
Modification of aspartoacylase for potential use in enzyme replacement therapy for the treatment of Canavan disease.
2007
2007
Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility
N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase. Abnormal levels of the enzyme leads to… 
2002
2002
Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder
Highly Cited
2000
Highly Cited
2000
Epileptic seizures induced by N-acetyl-l-aspartate in rats: in vivo and in vitro studies
2000
2000
Murine aspartoacylase: cloning, expression and comparison with the human enzyme.
Review
2000
Review
2000
Canavan’s spongiform leukodystrophy
Canavan disease (CD) is a globally distributed early-onset leukodystrophy. It is genetic in nature, and results from an… 
Review
1999
Review
1999
Hypothesis: Molecular water pumps and the aetiology of Canavan disease: A case of the sorcerer's apprentice
disease (CD; McKusick 271900) is a rare autosomal recessive genetic disCanavan order that is recognized by early onset and a… 
1993
1993
Bovine testis acylphosphatase: Purification and amino acid sequence
Two acylphosphatase molecular forms have been isolated from bovine testis. Their amino acid sequence was determined. One (ACY1… 
1989
1989
Aspartoacylase Deficiency: The Enzyme Defect in Canavan Disease
Spongy degeneration of the brain, Canavan disease (CD; McKusick 27190) is an autosomal recessive leukodystrophy (van Bogaert and… 
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