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ASPA gene
Known as:
AMINOACYLASE 2
, ASPA
, Canavan disease
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National Institutes of Health
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2 relations
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Aspartic Acid
Canavan Disease
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Modeling the Complete Catalytic Cycle of Aspartoacylase.
E. Kots
,
M. Khrenova
,
S. Lushchekina
,
S. Varfolomeev
,
B. Grigorenko
,
A. Nemukhin
Journal of Physical Chemistry B
2016
Corpus ID: 4959402
The complete catalytic cycle of aspartoacylase (ASPA), a zinc-dependent enzyme responsible for cleavage of N-acetyl-l-aspartate…
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2011
2011
Modification of aspartoacylase for potential use in enzyme replacement therapy for the treatment of Canavan disease.
Stephen P. Zano
,
R. Malik
,
S. Szucs
,
R. Matalon
,
R. Viola
Molecular Genetics and Metabolism
2011
Corpus ID: 5198774
2007
2007
Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility
S. Surendran
Molecular Biology Reports
2007
Corpus ID: 5674636
N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase. Abnormal levels of the enzyme leads to…
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2002
2002
Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder
T. Seki
,
H. Matsubayashi
,
+4 authors
M. Sasa
Neuroscience Letters
2002
Corpus ID: 24059367
Highly Cited
2000
Highly Cited
2000
Epileptic seizures induced by N-acetyl-l-aspartate in rats: in vivo and in vitro studies
T. Akimitsu
,
K. Kurisu
,
+8 authors
M. Sasa
Brain Research
2000
Corpus ID: 6245933
2000
2000
Murine aspartoacylase: cloning, expression and comparison with the human enzyme.
M. Namboodiri
,
A. Corigliano-Murphy
,
G. Jiang
,
M. Rollag
,
I. Provencio
Brain Research. Molecular Brain Research
2000
Corpus ID: 46740
Review
2000
Review
2000
Canavan’s spongiform leukodystrophy
M. Baslow
Journal of Molecular Neuroscience
2000
Corpus ID: 28504839
Canavan disease (CD) is a globally distributed early-onset leukodystrophy. It is genetic in nature, and results from an…
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Review
1999
Review
1999
Hypothesis: Molecular water pumps and the aetiology of Canavan disease: A case of the sorcerer's apprentice
M. Baslow
Journal of Inherited Metabolic Disease
1999
Corpus ID: 32061138
disease (CD; McKusick 271900) is a rare autosomal recessive genetic disCanavan order that is recognized by early onset and a…
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1993
1993
Bovine testis acylphosphatase: Purification and amino acid sequence
L. Pazzagli
,
G. Cappugi
,
G. Camici
,
G. Manao
,
G. Ramponi
Journal of Protein Chemistry
1993
Corpus ID: 46589677
Two acylphosphatase molecular forms have been isolated from bovine testis. Their amino acid sequence was determined. One (ACY1…
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1989
1989
Aspartoacylase Deficiency: The Enzyme Defect in Canavan Disease
R. Matalon
,
R. Kaul
,
+5 authors
M. Deanching
Journal of Inherited Metabolic Disease
1989
Corpus ID: 8265960
Spongy degeneration of the brain, Canavan disease (CD; McKusick 27190) is an autosomal recessive leukodystrophy (van Bogaert and…
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