ASPA gene

Current epileptic seizure "prediction" algorithms are generally based on the knowledge of seizure occurring time and analyze the… (More)

This clinical protocol describes virus-based gene transfer for Canavan disease, a childhood leukodystrophy. Canavan disease, also… (More)

Canavan disease is a devastating neurodegenerative childhood disease caused by mutations in aspartoacylase, an enzyme that… (More)

With the ultimate goal of developing safe and effective in vivo gene therapy for the treatment of Canavan disease and other… (More)

BACKGROUND Canavan disease (CD) is an autosomal recessive leukodystrophy characterized by deficiency of aspartoacylase (ASPA) and… (More)

Canavan disease is inherited as an autosomal recessive trait that is caused by the deficiency of aspartoacylase (ASPA). The… (More)

Canavan disease, or spongy degeneration of the brain, is a severe leukodystrophy caused by the deficiency of aspartoacylase (ASPA… (More)

Canavan disease, an autosomal recessive disorder, is characterized biochemically by N-acetylaspartic aciduria and aspartoacylase… (More)

An increased amount of N-acetylaspartic acid was found in urine and plasma of three patients, from two families, with the… (More)

The release of fluoride from a glass ionomer cement (ASPA) was compared with that from a silicate cement. Test specimens were… (More)