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Calcium Release Activated Calcium Channels

Known as: Calcium Release-Activated Channels, Calcium Release Activated Calcium Channels [Chemical/Ingredient], Calcium Release Activated Channels 
Specialized calcium channels that localize to the ENDOPLAMSIC RETICULUM and PLASMA MEMBRANE. They contain the pore subunit ORAI1 PROTEIN which is… 
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2019
Highly Cited
2019
Store-Operated Calcium Channels: From Function to Structure and Back Again.
Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of ion channels activated by the loss of… 
Highly Cited
2011
Highly Cited
2011
Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
ABSTRACT AMP-activated protein kinase (AMPK) is an energy sensor activated by increases in [AMP] or by oxidant stress (reactive… 
Highly Cited
2009
Highly Cited
2009
Decoding of Cytoplasmic Ca2+ Oscillations through the Spatial Signature Drives Gene Expression
Highly Cited
2009
Highly Cited
2009
STIM 1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai 1
Chan Young Park,1,7 Paul J. Hoover,2,7 Franklin M. Mullins,2,3 Priti Bachhawat,2,4 Elizabeth D. Covington,2 Stefan Raunser,5… 
Review
2009
Review
2009
Arachidonic acid, ARC channels, and Orai proteins.
Highly Cited
2007
Highly Cited
2007
Calcium Inhibition and Calcium Potentiation of Orai1, Orai2, and Orai3 Calcium Release-activated Calcium Channels*
The recent discoveries of Stim1 and Orai proteins have shed light on the molecular makeup of both the endoplasmic reticulum Ca2… 
Highly Cited
2007
Highly Cited
2007
Orai1 Mutations Alter Ion Permeation and Ca2+-dependent Fast Inactivation of CRAC Channels: Evidence for Coupling of Permeation and Gating
Ca2+ entry through store-operated Ca2+ release-activated Ca2+ (CRAC) channels is an essential trigger for lymphocyte activation… 
Highly Cited
2006
Highly Cited
2006
Sustained Activity of Calcium Release-activated Calcium Channels Requires Translocation of Mitochondria to the Plasma Membrane*
A rise of the intracellular Ca2+ concentration has multiple signaling functions. Sustained Ca2+ influx across plasma membrane… 
Highly Cited
1998
Highly Cited
1998
Slow Feedback Inhibition of Calcium Release-activated Calcium Current by Calcium Entry*
In many nonexcitable cells, depletion of the inositol 1,4,5-trisphosphate-sensitive store activates Ca2+ influx, a process termed… 
Highly Cited
1995
Highly Cited
1995
Calcium and barium permeation through calcium release-activated calcium (CRAC) channels
  • M. Hoth
  • Pflügers Archiv
  • 1995
  • Corpus ID: 8137071
A Ca2+ current activated by store depletion has been described recently in several cell types and has been termed ICRAC (for Ca2… 
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