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Calcium Channels, R-Type

Known as: Calcium Channels, R Type, R-Type Calcium Channel, R Type VDCC 
CALCIUM CHANNELS located in the neurons of the brain. They are inhibited by the marine snail toxin, omega conotoxin MVIIC.
National Institutes of Health

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CACNA1E protein, humanCacna1e protein, rat

Papers overview

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Highly Cited
2012
Highly Cited
2012
Quantitative Regional and Ultrastructural Localization of the Cav2.3 Subunit of R-type Calcium Channel in Mouse Brain
R-type calcium channels (RTCCs) are well known for their role in synaptic plasticity, but little is known about their subcellular… 
Highly Cited
2010
Highly Cited
2010
Functional interplay between NMDA receptors, SK channels and voltage‐gated Ca2+ channels regulates synaptic excitability in the medial prefrontal cortex
Synaptic activity in the medial prefrontal cortex (mPFC) is fundamental for higher cognitive functions such as working memory… 
Highly Cited
2008
Highly Cited
2008
Spine Neck Plasticity Controls Postsynaptic Calcium Signals through Electrical Compartmentalization
Dendritic spines have been proposed to function as electrical compartments for the active processing of local synaptic signals… 
Review
2006
Review
2006
Pharmacology and drug discovery for T-type calcium channels.
Voltage-gated calcium channels are found in the plasma membrane of many excitable and non-excitable cells. When open, they permit… 
Highly Cited
2005
Highly Cited
2005
R-Type Calcium Channels Contribute to Afterdepolarization and Bursting in Hippocampal CA1 Pyramidal Neurons
Action potentials in pyramidal neurons are typically followed by an afterdepolarization (ADP), which in many cells contributes to… 
Highly Cited
2004
Highly Cited
2004
Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel α1 subunits in the dorsal horn of spinal cord in mice
Highly Cited
2002
Highly Cited
2002
Molecular basis of R-type calcium channels in central amygdala neurons of the mouse
R-type Ca2+ channels play a critical role in coupling excitability to dendritic Ca2+ influx and neuronal secretion. Unlike other… 
Highly Cited
2001
Highly Cited
2001
Presynaptic R-Type Calcium Channels Contribute to Fast Excitatory Synaptic Transmission in the Rat Hippocampus
The possibility that R-type calcium channels contribute to fast glutamatergic transmission in the hippocampus has been assessed… 
Highly Cited
1998
Highly Cited
1998
Preferential Closed-State Inactivation of Neuronal Calcium Channels
Highly Cited
1996
Highly Cited
1996
Functional Diversity of P-Type and R-Type Calcium Channels in Rat Cerebellar Neurons
By combining single-channel and whole-cell patch-clamp recordings, we have established the sensitivity to ω-agatoxin IVA and… 
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