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Channel-Mediated Tonic GABA Release from Glia
TLDR
It is reported that tonic inhibition in the cerebellum is due to GABA being released from glial cells by permeation through the Bestrophin 1 (Best1) anion channel, and it is demonstrated that GABA directly permeates through Best1 to yield GABA release and that Tonic inhibition is eliminated by silencing of Best1. Expand
Phospholipase Cβ Serves as a Coincidence Detector through Its Ca2+ Dependency for Triggering Retrograde Endocannabinoid Signal
TLDR
PLCbeta1 serves as a coincidence detector through its Ca(2+) dependency for endocannabinoid release in hippocampal neurons and is detected by phospholipase Cbeta1 in hippocampusal neurons. Expand
Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
TLDR
It is found that mice (observers) developed freezing behavior by observing other mice (demonstrators) receive repetitive foot shocks, and the functional involvement of the affective pain system and Cav1.2 channels of the ACC in observational social fear is demonstrated. Expand
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
TLDR
The molecular basis of these phenotypes is determined and it is shown that PLC-β1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor, whereas P LC-β4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PL-β isoenzymes are used to generate different functions in the brain. Expand
An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates
TLDR
The results of a search for sequences homologous to the per locus DNA in the genomic DNA of several species of vertebrates show an unusual, tandemly repeated sequence forming a portion of the 4.5-kb per transcript is homologously to DNA in chicken, mouse and man. Expand
Lack of the Burst Firing of Thalamocortical Relay Neurons and Resistance to Absence Seizures in Mice Lacking α1G T-Type Ca2+ Channels
TLDR
The modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway. Expand
Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow
TLDR
Using TTA-P2, the first direct demonstration of the presence of a window component of Ca2+ channels in neurons and its contribution to the resting membrane potential of thalamic neurons and to the Up state of their intrinsically generated slow (<1 Hz) oscillation is provided. Expand
Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex
TLDR
It is proposed that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems and places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism. Expand
Thalamic Spindles Promote Memory Formation during Sleep through Triple Phase-Locking of Cortical, Thalamic, and Hippocampal Rhythms
TLDR
It is shown that only thalamic spindles induced in-phase with cortical slow oscillation up-states, but not out-of-phase-inducedSpindles, improve consolidation of hippocampus-dependent memory during sleep. Expand
Presynaptic N‐type and P/Q‐type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice
TLDR
The results suggest that the developmental switch of presynaptic Ca2+ channels from N‐ to P/Q‐type may serve to increase synaptic efficacy at high frequencies of activity, securing high‐fidelity synaptic transmission. Expand
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