Preferential Closed-State Inactivation of Neuronal Calcium Channels

@article{Patil1998PreferentialCI,
  title={Preferential Closed-State Inactivation of Neuronal Calcium Channels},
  author={Parag G. Patil and David L. Brody and David T. Yue},
  journal={Neuron},
  year={1998},
  volume={20},
  pages={1027-1038}
}
We have investigated the inactivation mechanism of neuronal N-, P/Q-, and R-type calcium channels. Although channels inactivate slowly during square-pulse depolarization, as observed previously, we now find that they inactivate profoundly during a train of action potential (AP) waveforms. The apparent paradox arises from a voltage-dependent mechanism in which channels inactivate preferentially from intermediate closed states along the activation pathway. Inactivation can therefore extend beyond… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 108 CITATIONS, ESTIMATED 58% COVERAGE

G-proteins modulate cumulative inactivation of N-type (Cav2.2) calcium channels.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2006
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Differential control of synaptic and ectopic vesicular release of glutamate.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2004
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Decoding of synaptic voltage waveforms by specific classes of recombinant high-threshold Ca(2+) channels.

  • The Journal of physiology
  • 2003
VIEW 6 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Systematic identification of splice variants in human P/Q-type channel alpha1(2.1) subunits: implications for current density and Ca2+-dependent inactivation.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2002
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND

U-type inactivation of Kv3.1 and Shaker potassium channels.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1998
2019

CITATION STATISTICS

  • 15 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

Short-term synaptic plasticity.

  • Annual review of physiology
  • 1989
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

metabotropic glutamate receptor

K. J. Gingrich, J. H. Byrne
  • 1985
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The neural code

M. V. Tsodyks, H. Markram
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Pre - and post - sympathetic neurons . II . Inactivation

J. G. G. Borst, F. Helmchen, B. Sakmann
  • J . Physiol .
  • 1995
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

State-dependent inactivation of K+ currents in rat type II alveolar epithelial cells

  • The Journal of general physiology
  • 1990
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Calcium currents

S. W. Jones, T. N. Marks
  • J. Physiol
  • 1989
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Presynaptic inhibition of elicited neurotransmitter release

  • Trends in Neurosciences
  • 1997
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL